benzyl (2R)-2-benzyl-3-<<<2-(4-methylpiperazin-1-yl)ethyl>methylamino>carbonyl>propionate

Base Information

• Chemical Name: benzyl (2R)-2-benzyl-3-<<<2-(4-methylpiperazin-1-yl)ethyl>methylamino>carbonyl>propionate
• CAS No.: 122225-94-9
• Molecular Formula: C₂₆H₃₅N₃O₃
• Molecular Weight: 437.582

Synonyms:benzyl (2R)-2-benzyl-3-<<<2-(4-methylpiperazin-1-yl)ethyl>methylamino>carbonyl>propionate

Chemical Property of benzyl (2R)-2-benzyl-3-<<<2-(4-methylpiperazin-1-yl)ethyl>methylamino>carbonyl>propionate

Chemical Property:

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Technology Process of benzyl (2R)-2-benzyl-3-<<<2-(4-methylpiperazin-1-yl)ethyl>methylamino>carbonyl>propionate

There total 2 articles about benzyl (2R)-2-benzyl-3-<<<2-(4-methylpiperazin-1-yl)ethyl>methylamino>carbonyl>propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl (2R)-2-benzyl-3-<<(2-hydroxyethyl)methylamino>carbonyl>propionate (122226-17-9) → benzyl (2R)-2-benzyl-3-<<<2-(4-methylpiperazin-1-yl)ethyl>methylamino>carbonyl>propionate (122225-94-9)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 1.5 h / -78 °C

2: Et₃N / CH₂Cl₂ / 2 h / Heating

With triethylamine; In dichloromethane;

DOI:10.1021/jm00056a006

Reference yield:

1-methyl-piperazine (109-01-3) + (R)-2-Benzyl-N-(2-methanesulfonyloxy-ethyl)-N-methyl-succinamic acid benzyl ester (1027920-53-1) → benzyl (2R)-2-benzyl-3-<<<2-(4-methylpiperazin-1-yl)ethyl>methylamino>carbonyl>propionate (122225-94-9)

Guidance literature:

With triethylamine; In dichloromethane; for 2h; Yield given; Heating;

DOI:10.1021/jm00056a006

Reference yield: 80.0%

benzyl (2R)-2-benzyl-3-<<<2-(4-methylpiperazin-1-yl)ethyl>methylamino>carbonyl>propionate (122225-94-9) → (2R)-2-benzyl-3-<<<2-(4-methylpiperazin-1-yl)ethyl>methylamino>carbonyl>propionic acid (122225-95-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 2h;

DOI:10.1021/jm00056a006

upstream raw materials:

1-methyl-piperazine

(R)-2-Benzyl-N-(2-methanesulfonyloxy-ethyl)-N-methyl-succinamic acid benzyl ester

benzyl (2R)-2-benzyl-3-<<(2-hydroxyethyl)methylamino>carbonyl>propionate

Downstream raw materials:

(2R)-2-benzyl-3-<<<2-(4-methylpiperazin-1-yl)ethyl>methylamino>carbonyl>propionic acid

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