1-(2-cyclopropyl-1-methyl-1H-benzimidazol-6-yl)-4-((2-fluorobenzyl)oxy)pyridin-2(1H)-one

Base Information

Chemical Name:1-(2-cyclopropyl-1-methyl-1H-benzimidazol-6-yl)-4-((2-fluorobenzyl)oxy)pyridin-2(1H)-one
CAS No.:1447911-98-9
Molecular Formula:C₂₃H₂₀FN₃O₂
Molecular Weight:389.429
Hs Code.:

Synonyms:1-(2-cyclopropyl-1-methyl-1H-benzimidazol-6-yl)-4-((2-fluorobenzyl)oxy)pyridin-2(1H)-one

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Chemical Property of 1-(2-cyclopropyl-1-methyl-1H-benzimidazol-6-yl)-4-((2-fluorobenzyl)oxy)pyridin-2(1H)-one

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Technology Process of 1-(2-cyclopropyl-1-methyl-1H-benzimidazol-6-yl)-4-((2-fluorobenzyl)oxy)pyridin-2(1H)-one

There total 5 articles about 1-(2-cyclopropyl-1-methyl-1H-benzimidazol-6-yl)-4-((2-fluorobenzyl)oxy)pyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 321-23-3
4-bromo-2-fluoronitrobenzene

: 1447911-98-9
1-(2-cyclopropyl-1-methyl-1H-benzimidazol-6-yl)-4-((2-fluorobenzyl)oxy)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: ethanol; methanol / 1 h / 20 °C

2.1: zinc; ammonium chloride / methanol; water / 3 h / 20 °C

2.2: 3 h / 120 °C

3.1: potassium carbonate; copper(l) iodide; N,N`-dimethylethylenediamine / dimethyl sulfoxide / 1 h / 150 °C / Inert atmosphere

4.1: trifluoroacetic acid / 4 h / 130 °C

5.1: sodium hydride / mineral oil; tetrahydrofuran / 0 - 20 °C

5.2: 12 h / 20 °C

With copper(l) iodide; sodium hydride; potassium carbonate; ammonium chloride; trifluoroacetic acid; N,N`-dimethylethylenediamine; zinc; In tetrahydrofuran; methanol; ethanol; water; dimethyl sulfoxide; mineral oil;

Reference yield:

: 446-48-0
o-fluorobenzyl bromide

: 1447910-97-5
1-(2-cyclopropyl-1-methyl-1H-benzimidazol-6-yl)-4-hydroxypyridin-2(1H)-one

: 1447911-98-9
1-(2-cyclopropyl-1-methyl-1H-benzimidazol-6-yl)-4-((2-fluorobenzyl)oxy)pyridin-2(1H)-one

Guidance literature:: 1-(2-cyclopropyl-1-methyl-1H-benzimidazol-6-yl)-4-hydroxypyridin-2(1H)-one; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃;

o-fluorobenzyl bromide; In tetrahydrofuran; mineral oil; at 20 ℃; for 12h;

Reference yield:

: 302800-13-1
5-bromo-N-methyl-2-nitroaniline

: 1447911-98-9
1-(2-cyclopropyl-1-methyl-1H-benzimidazol-6-yl)-4-((2-fluorobenzyl)oxy)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: zinc; ammonium chloride / methanol; water / 3 h / 20 °C

1.2: 3 h / 120 °C

2.1: potassium carbonate; copper(l) iodide; N,N`-dimethylethylenediamine / dimethyl sulfoxide / 1 h / 150 °C / Inert atmosphere

3.1: trifluoroacetic acid / 4 h / 130 °C

4.1: sodium hydride / mineral oil; tetrahydrofuran / 0 - 20 °C

4.2: 12 h / 20 °C

With copper(l) iodide; sodium hydride; potassium carbonate; ammonium chloride; trifluoroacetic acid; N,N`-dimethylethylenediamine; zinc; In tetrahydrofuran; methanol; water; dimethyl sulfoxide; mineral oil;