-O-<<(tert-butyloxy)carbonyl>-S-(acetamidomethyl)-L-cysteinyl-L-valyl>-D-seryl>-N-methyl-L-alanine

Base Information

Chemical Name:-O-<<(tert-butyloxy)carbonyl>-S-(acetamidomethyl)-L-cysteinyl-L-valyl>-D-seryl>-N-methyl-L-alanine
CAS No.:78166-95-7
Molecular Formula:C₃₁H₄₇N₅O₁₁S
Molecular Weight:697.807
Hs Code.:

<N-<(Benzyloxy)carbonyl>-O-<<(tert-butyloxy)carbonyl>-S-(acetamidomethyl)-L-cysteinyl-L-valyl>-D-seryl>-N-methyl-L-alanine

Synonyms:-O-<<(tert-butyloxy)carbonyl>-S-(acetamidomethyl)-L-cysteinyl-L-valyl>-D-seryl>-N-methyl-L-alanine

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Chemical Property of -O-<<(tert-butyloxy)carbonyl>-S-(acetamidomethyl)-L-cysteinyl-L-valyl>-D-seryl>-N-methyl-L-alanine

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Technology Process of -O-<<(tert-butyloxy)carbonyl>-S-(acetamidomethyl)-L-cysteinyl-L-valyl>-D-seryl>-N-methyl-L-alanine

There total 2 articles about -O-<<(tert-butyloxy)carbonyl>-S-(acetamidomethyl)-L-cysteinyl-L-valyl>-D-seryl>-N-methyl-L-alanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 78166-94-6
-O-<<(tert-butyloxy)carbonyl>-S-(acetamidomethyl)-L-cysteinyl-L-valyl>-D-seryl>-N-methyl-L-alanine 2,2,2-Trichloroethyl Ester

: 78166-95-7
-O-<<(tert-butyloxy)carbonyl>-S-(acetamidomethyl)-L-cysteinyl-L-valyl>-D-seryl>-N-methyl-L-alanine

Guidance literature:: With acetic acid; zinc; 1.) 0 deg C, 2 h, 2.) room temperature;
DOI:10.1021/jo00330a010

Reference yield:

: 78166-92-4
-D-seryl>-N-methyl-L-alanine 2,2,2-Trichloroethyl Ester

: 78166-95-7
-O-<<(tert-butyloxy)carbonyl>-S-(acetamidomethyl)-L-cysteinyl-L-valyl>-D-seryl>-N-methyl-L-alanine

Guidance literature:: Multi-step reaction with 3 steps

1: 87.5 percent / 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / 4-(dimethylamino)pyridine / CH₂Cl₂ / 1.) 0 deg C, 3 h, 2.) room temperature, overnight

2: 1.)trifluoroacetic acid, 2.) 1-hydroxybenzotriazole, 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / 1.) 30 min, room temperature, 2.) THF, 1 h, 0 deg C, 3.) 5 h, room temperature

3: 72 percent / Zn(powder), 90percent aq. CH₃COOH / 1.) 0 deg C, 2 h, 2.) room temperature

With benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; zinc; dmap; In dichloromethane;
DOI:10.1021/jo00330a010

Reference yield: 87.5%

: 78186-12-6
-O-<-L-valyl>-D-seryl>-N-methyl-L-alanine 2,2,2-Trichloroethyl Ester

: 78166-95-7
-O-<<(tert-butyloxy)carbonyl>-S-(acetamidomethyl)-L-cysteinyl-L-valyl>-D-seryl>-N-methyl-L-alanine

: 78166-96-8
-O-<<<-O-<-S-(acetamidomethyl)-L-cysteinyl>-L-valyl>-D-seryl>-N-methyl-L-alanyl>-S-(acetamidomethyl)-L-cysteinyl>-L-valyl>-D-seryl>-N-methyl-L-alanine 2,2,2-Trichloroethyl Ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; 1.) 0 deg C, 1 h, 2.) room temperature, 6 h;
DOI:10.1021/jo00330a010