ethyl (2S,3S)-2-benzamidomethyl-4-fluoro-3-hydroxybutanoate

Base Information

• Chemical Name: ethyl (2S,3S)-2-benzamidomethyl-4-fluoro-3-hydroxybutanoate
• CAS No.: 1161374-57-7
• Molecular Formula: C₁₄H₁₈FNO₄
• Molecular Weight: 283.3
• Mol file: 1161374-57-7.mol

Synonyms:ethyl (2S,3S)-2-benzamidomethyl-4-fluoro-3-hydroxybutanoate

Chemical Property of ethyl (2S,3S)-2-benzamidomethyl-4-fluoro-3-hydroxybutanoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of ethyl (2S,3S)-2-benzamidomethyl-4-fluoro-3-hydroxybutanoate

There total 2 articles about ethyl (2S,3S)-2-benzamidomethyl-4-fluoro-3-hydroxybutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

ethyl 2-benzamidomethyl-4-fluoro-3-oxo-butanoate (1161374-53-3) → ethyl (2S,3S)-2-benzamidomethyl-4-fluoro-3-hydroxybutanoate (1161374-57-7) + ethyl 2-benzamidomethyl-3-hydroxy-4-fluorobutanoate

Guidance literature:

With formic acid; triethylamine; [RuCl₂(1,3,5-Et₃C₆H₃)]2; (1S,2S)-N-(N,N-dimethylsulfamoyl)-1,2-diphenylethylenediamine; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

Reference yield:

ethyl 2-benzamidomethyl-4-fluoro-3-oxo-butanoate (1161374-53-3) → C14H18FNO4 + ethyl (2S,3S)-2-benzamidomethyl-4-fluoro-3-hydroxybutanoate (1161374-57-7)

Guidance literature:

With formic acid; [RuCl₂(1,3,5-triethylbenzene)]2; triethylamine; (1S,2S)-N-(N,N-dimethylsulfamoyl)-1,2-diphenylethylenediamine; In N,N-dimethyl-formamide; at 20 ℃; optical yield given as %de; Inert atmosphere;

DOI:10.1016/j.tetlet.2009.03.111

Reference yield: 85.0%

ethyl (2S,3S)-2-benzamidomethyl-4-fluoro-3-hydroxybutanoate (1161374-57-7) → ethyl (E)-2-(benzamidomethyl)-4-fluorobut-2-enoate (1161374-75-9)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.tetlet.2009.03.111

upstream raw materials:

ethyl 2-benzamidomethyl-4-fluoro-3-oxo-butanoate

Downstream raw materials:

ethyl (E)-2-(benzamidomethyl)-4-fluorobut-2-enoate