2-benzo[1,3]dioxol-5-yl-6-(toluene-4-sulfonyl)-1,6-dihydro-2H-3-oxa-6-aza-as-indacene-1-carbaldehyde

Base Information

• Chemical Name: 2-benzo[1,3]dioxol-5-yl-6-(toluene-4-sulfonyl)-1,6-dihydro-2H-3-oxa-6-aza-as-indacene-1-carbaldehyde
• CAS No.: 929198-16-3
• Molecular Formula: C₂₅H₁₉NO₆S
• Molecular Weight: 461.495

Synonyms:2-benzo[1,3]dioxol-5-yl-6-(toluene-4-sulfonyl)-1,6-dihydro-2H-3-oxa-6-aza-as-indacene-1-carbaldehyde

Chemical Property of 2-benzo[1,3]dioxol-5-yl-6-(toluene-4-sulfonyl)-1,6-dihydro-2H-3-oxa-6-aza-as-indacene-1-carbaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-benzo[1,3]dioxol-5-yl-6-(toluene-4-sulfonyl)-1,6-dihydro-2H-3-oxa-6-aza-as-indacene-1-carbaldehyde

There total 11 articles about 2-benzo[1,3]dioxol-5-yl-6-(toluene-4-sulfonyl)-1,6-dihydro-2H-3-oxa-6-aza-as-indacene-1-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

[2-benzo[1,3]dioxol-5-yl-6-(toluene-4-sulfonyl)-1,6-dihydro-2H-3-oxa-6-aza-as-indacen-1-yl]-methanol (929198-08-3) → 2-benzo[1,3]dioxol-5-yl-6-(toluene-4-sulfonyl)-1,6-dihydro-2H-3-oxa-6-aza-as-indacene-1-carbaldehyde (929198-16-3)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; for 2.5h;

DOI:10.1002/ejoc.200600922

Reference yield:

N-(4-hydroxy-5,8-dihydro-naphthalen-1-yl)-4-methyl-benzenesulfonamide (850888-88-9) → 2-benzo[1,3]dioxol-5-yl-6-(toluene-4-sulfonyl)-1,6-dihydro-2H-3-oxa-6-aza-as-indacene-1-carbaldehyde (929198-16-3)

Guidance literature:

Multi-step reaction with 7 steps

1.1: 94 percent / Et₃N / tetrahydrofuran / 24 h / 20 °C

2.1: osmium tetroxide; N-methylmorpholine-N-oxide / tetrahydrofuran; H₂O / 72 h

2.2: NaIO₄ / tetrahydrofuran; H₂O / 4 h

2.3: 80 percent / conc. sulfuric acid / tetrahydrofuran

3.1: NaClO₂; NaH₂PO₄ / 2-methyl-propan-2-ol; various solvent(s) / 3.5 h / 20 °C

4.1: 3.22 g / methanol; benzene / 20 °C

5.1: 76 percent / dicyclohexyliodoborane; Et₃N / CCl₄ / 24 h / 20 °C

6.1: 70 percent / DIBAL / tetrahydrofuran / 20 °C

7.1: 83 percent / Dess-Martin periodinane / CH₂Cl₂ / 2.5 h

With sodium chlorite; sodium dihydrogenphosphate; osmium(VIII) oxide; B-iododicyclohexylborane; diisobutylaluminium hydride; Dess-Martin periodane; 4-methylmorpholine N-oxide; triethylamine; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; water; tert-butyl alcohol; benzene; 7.1: Dess-Martin oxidation;

DOI:10.1002/ejoc.200600922

Reference yield:

2,2-dimethyl-propionic acid 4-(2-oxo-ethyl)-1-(toluene-4-sulfonyl)-1H-indol-5-yl ester (929198-12-9) → 2-benzo[1,3]dioxol-5-yl-6-(toluene-4-sulfonyl)-1,6-dihydro-2H-3-oxa-6-aza-as-indacene-1-carbaldehyde (929198-16-3)

Guidance literature:

Multi-step reaction with 5 steps

1: NaClO₂; NaH₂PO₄ / 2-methyl-propan-2-ol; various solvent(s) / 3.5 h / 20 °C

2: 3.22 g / methanol; benzene / 20 °C

3: 76 percent / dicyclohexyliodoborane; Et₃N / CCl₄ / 24 h / 20 °C

4: 70 percent / DIBAL / tetrahydrofuran / 20 °C

5: 83 percent / Dess-Martin periodinane / CH₂Cl₂ / 2.5 h

With sodium chlorite; sodium dihydrogenphosphate; B-iododicyclohexylborane; diisobutylaluminium hydride; Dess-Martin periodane; triethylamine; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; tert-butyl alcohol; benzene; 5: Dess-Martin oxidation;

DOI:10.1002/ejoc.200600922

upstream raw materials:

[2-benzo[1,3]dioxol-5-yl-6-(toluene-4-sulfonyl)-1,6-dihydro-2H-3-oxa-6-aza-as-indacen-1-yl]-methanol

N-(4-hydroxy-5,8-dihydro-naphthalen-1-yl)-4-methyl-benzenesulfonamide

2,2-dimethyl-propionic acid 4-(2-oxo-ethyl)-1-(toluene-4-sulfonyl)-1H-indol-5-yl ester

2,2-dimethyl-propionic acid 4-(toluene-4-sulfonylamino)-5,8-dihydro-naphthalen-1-yl ester

Downstream raw materials:

2-benzo[1,3]dioxol-5-yl-8-(2-nitro-ethyl)-6-(toluene-4-sulfonyl)-1,6-dihydro-2H-3-oxa-6-aza-as-indacene-1-carboxylic acid methyl ester

2-benzo[1,3]dioxol-5-yl-6-(toluene-4-sulfonyl)-1,6-dihydro-2H-3-oxa-6-aza-as-indacene-1-carboxylic acid methyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 929198-16-3 2-benzo[1,3]dioxol-5-yl-6-(toluene-4-sulfonyl)-1,6-dihydro-2H-3-oxa-6-aza-as-indacene-1-carbaldehyde

Send

Send

Metric Ton KG G Pound L ML

Send

Send