tert-butyl {(1R)-2-oxo-1-phenyl-2-[(2S)-2-({2-[4-({[(2S)-1-(phenylacetyl)pyrrolidin-2-yl]carbonyl}amino)phenyl]-1H-indol-5-yl}carbamoyl)pyrrolidin-1-yl]ethyl}carbamate

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Chemical Name:tert-butyl {(1R)-2-oxo-1-phenyl-2-[(2S)-2-({2-[4-({[(2S)-1-(phenylacetyl)pyrrolidin-2-yl]carbonyl}amino)phenyl]-1H-indol-5-yl}carbamoyl)pyrrolidin-1-yl]ethyl}carbamate
CAS No.:1246468-81-4
Molecular Formula:C₄₅H₄₈N₆O₆
Molecular Weight:768.913
Hs Code.:

tert-butyl {(1R)-2-oxo-1-phenyl-2-[(2S)-2-({2-[4-({[(2S)-1-(phenylacetyl)pyrrolidin-2-yl]carbonyl}amino)phenyl]-1H-indol-5-yl}carbamoyl)pyrrolidin-1-yl]ethyl}carbamate

Synonyms:tert-butyl {(1R)-2-oxo-1-phenyl-2-[(2S)-2-({2-[4-({[(2S)-1-(phenylacetyl)pyrrolidin-2-yl]carbonyl}amino)phenyl]-1H-indol-5-yl}carbamoyl)pyrrolidin-1-yl]ethyl}carbamate

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Chemical Property of tert-butyl {(1R)-2-oxo-1-phenyl-2-[(2S)-2-({2-[4-({[(2S)-1-(phenylacetyl)pyrrolidin-2-yl]carbonyl}amino)phenyl]-1H-indol-5-yl}carbamoyl)pyrrolidin-1-yl]ethyl}carbamate

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Technology Process of tert-butyl {(1R)-2-oxo-1-phenyl-2-[(2S)-2-({2-[4-({[(2S)-1-(phenylacetyl)pyrrolidin-2-yl]carbonyl}amino)phenyl]-1H-indol-5-yl}carbamoyl)pyrrolidin-1-yl]ethyl}carbamate

There total 6 articles about tert-butyl {(1R)-2-oxo-1-phenyl-2-[(2S)-2-({2-[4-({[(2S)-1-(phenylacetyl)pyrrolidin-2-yl]carbonyl}amino)phenyl]-1H-indol-5-yl}carbamoyl)pyrrolidin-1-yl]ethyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1246471-17-9
C₃₂H₃₅N₅O₄

: 2752-38-7
(S)-1-(2-phenylacetyl)pyrrolidine-2-carboxylic acid

: 1246468-81-4
tert-butyl {(1R)-2-oxo-1-phenyl-2-[(2S)-2-({2-[4-({[(2S)-1-(phenylacetyl)pyrrolidin-2-yl]carbonyl}amino)phenyl]-1H-indol-5-yl}carbamoyl)pyrrolidin-1-yl]ethyl}carbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In acetonitrile; at 20 ℃;

Reference yield:

: 100-19-6
(4-nitrophenyl)ethanone

: 1246468-81-4
tert-butyl {(1R)-2-oxo-1-phenyl-2-[(2S)-2-({2-[4-({[(2S)-1-(phenylacetyl)pyrrolidin-2-yl]carbonyl}amino)phenyl]-1H-indol-5-yl}carbamoyl)pyrrolidin-1-yl]ethyl}carbamate

Guidance literature:: Multi-step reaction with 6 steps

1: acetic acid / ethanol / 5 h / Reflux

2: Polyphosphoric acid / 1 h / 80 °C

3: tri-tert-butyl phosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium hexamethyldisilazane / tetrahydrofuran; hexane / Reflux

4: HATU; N-ethyl-N,N-diisopropylamine / acetonitrile / 25 °C

5: hydrogen; palladium on activated charcoal / methanol / 1 h / 25 °C

6: HATU; N-ethyl-N,N-diisopropylamine / acetonitrile / 25 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; palladium on activated charcoal; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; ethanol; hexane; acetonitrile;

Reference yield:

: 1056148-48-1
C₁₄H₁₁N₃O₂

: 1246468-81-4
tert-butyl {(1R)-2-oxo-1-phenyl-2-[(2S)-2-({2-[4-({[(2S)-1-(phenylacetyl)pyrrolidin-2-yl]carbonyl}amino)phenyl]-1H-indol-5-yl}carbamoyl)pyrrolidin-1-yl]ethyl}carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: HATU; N-ethyl-N,N-diisopropylamine / acetonitrile / 25 °C

2: hydrogen; palladium on activated charcoal / methanol / 1 h / 25 °C

3: HATU; N-ethyl-N,N-diisopropylamine / acetonitrile / 25 °C

With palladium on activated charcoal; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; In methanol; acetonitrile;