(1R,2R,4R)-Bicyclo[2.2.1]hept-5-ene-2-carboxylic acid (1S,2R,3S,4R)-3-benzyloxycarbonylamino-4,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester

Base Information

Chemical Name:(1R,2R,4R)-Bicyclo[2.2.1]hept-5-ene-2-carboxylic acid (1S,2R,3S,4R)-3-benzyloxycarbonylamino-4,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester
CAS No.:129064-57-9
Molecular Formula:C₂₆H₃₃NO₄
Molecular Weight:423.552
Hs Code.:

Synonyms:(1R,2R,4R)-Bicyclo[2.2.1]hept-5-ene-2-carboxylic acid (1S,2R,3S,4R)-3-benzyloxycarbonylamino-4,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester

Suppliers and Price of (1R,2R,4R)-Bicyclo[2.2.1]hept-5-ene-2-carboxylic acid (1S,2R,3S,4R)-3-benzyloxycarbonylamino-4,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1R,2R,4R)-Bicyclo[2.2.1]hept-5-ene-2-carboxylic acid (1S,2R,3S,4R)-3-benzyloxycarbonylamino-4,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1R,2R,4R)-Bicyclo[2.2.1]hept-5-ene-2-carboxylic acid (1S,2R,3S,4R)-3-benzyloxycarbonylamino-4,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester

There total 1 articles about (1R,2R,4R)-Bicyclo[2.2.1]hept-5-ene-2-carboxylic acid (1S,2R,3S,4R)-3-benzyloxycarbonylamino-4,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 129064-40-0
(1S,2R,6S,7R)-4-(1R,2R,4R)-Bicyclo[2.2.1]hept-5-en-2-yl-7,10,10-trimethyl-3-oxa-5-aza-tricyclo[5.2.1.0^2,6]dec-4-ene

: 501-53-1,94274-21-2
benzyl chloroformate

: 129064-57-9
(1R,2R,4R)-Bicyclo[2.2.1]hept-5-ene-2-carboxylic acid (1S,2R,3S,4R)-3-benzyloxycarbonylamino-4,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester

Guidance literature:: With sodium hydrogencarbonate; In dichloromethane; water; for 6h; Ambient temperature;

Reference yield:

: 129064-57-9
(1R,2R,4R)-Bicyclo[2.2.1]hept-5-ene-2-carboxylic acid (1S,2R,3S,4R)-3-benzyloxycarbonylamino-4,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester

: 129064-44-4
Phosphoric acid (3S,4R)-3-tert-butoxy-4-((1S,2R,6S,7R)-7,10,10-trimethyl-3-oxa-5-aza-tricyclo[5.2.1.0^2,6]dec-4-en-4-yl)-cyclohex-1-enyl ester diphenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / aq. NaOH / methanol / 14 h / 80 °C

2: 97 percent / Et₃N / CH₂Cl₂ / 5 h / Ambient temperature

3: 86 percent / t-BuOK, 18-crown-6 ether, phenothiazine / tetrahydrofuran / 0.25 h / 0 °C

4: 63 percent / trifluoroacetic anhydride, CaCO₃ / CH₂Cl₂ / 0.33 h / -40 °C

With sodium hydroxide; 10H-phenothiazine; 18-crown-6 ether; potassium tert-butylate; triethylamine; trifluoroacetic anhydride; calcium carbonate; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 129064-57-9
(1R,2R,4R)-Bicyclo[2.2.1]hept-5-ene-2-carboxylic acid (1S,2R,3S,4R)-3-benzyloxycarbonylamino-4,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester

: 129170-56-5
(1S,2R,6S,7R)-4-((1R,2S,3R,4S)-3-Benzenesulfonyl-bicyclo[2.2.1]hept-5-en-2-yl)-7,10,10-trimethyl-3-oxa-5-aza-tricyclo[5.2.1.0^2,6]dec-4-ene

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / aq. NaOH / methanol / 14 h / 80 °C

2: 100 percent / aq. Na₂CO₃ / CH₂Cl₂ / 0.5 h / 20 °C

3: 73 percent / POCl₃ / toluene / 0.25 h / 100 °C

4: 23 percent / 3-chloroperbenzoic acid / ethyl acetate / 6 h / Ambient temperature

5: 38 percent / trifluoroacetic anhydride / CH₂Cl₂ / 4 h / -100 °C

With sodium hydroxide; sodium carbonate; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; trichlorophosphate; In methanol; dichloromethane; ethyl acetate; toluene;