(2R)-methyl-2-tert-butoxycarbonylamino-3-(4'-dibenzofuran-4-yl-biphenyl-4-ylmethylsulfanyl)-propionate

Base Information

Chemical Name:(2R)-methyl-2-tert-butoxycarbonylamino-3-(4'-dibenzofuran-4-yl-biphenyl-4-ylmethylsulfanyl)-propionate
CAS No.:796071-10-8
Molecular Formula:C₃₄H₃₃NO₅S
Molecular Weight:567.706
Hs Code.:

Synonyms:(2R)-methyl-2-tert-butoxycarbonylamino-3-(4'-dibenzofuran-4-yl-biphenyl-4-ylmethylsulfanyl)-propionate

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Chemical Property of (2R)-methyl-2-tert-butoxycarbonylamino-3-(4'-dibenzofuran-4-yl-biphenyl-4-ylmethylsulfanyl)-propionate

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Technology Process of (2R)-methyl-2-tert-butoxycarbonylamino-3-(4'-dibenzofuran-4-yl-biphenyl-4-ylmethylsulfanyl)-propionate

There total 7 articles about (2R)-methyl-2-tert-butoxycarbonylamino-3-(4'-dibenzofuran-4-yl-biphenyl-4-ylmethylsulfanyl)-propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 796071-09-5
methanesulfonic acid 4'-dibenzofuran-4-yl-biphenyl-4-yl methyl ester

: 172749-96-1
N-[(tert-butoxy)carbonyl]-L-cysteine methyl ester

: 796071-10-8
(2R)-methyl-2-tert-butoxycarbonylamino-3-(4'-dibenzofuran-4-yl-biphenyl-4-ylmethylsulfanyl)-propionate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 2 - 3h;

Reference yield:

: 955959-84-9
4-(4-bromophenyl)dibenzofuran

: 796071-10-8
(2R)-methyl-2-tert-butoxycarbonylamino-3-(4'-dibenzofuran-4-yl-biphenyl-4-ylmethylsulfanyl)-propionate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 2 - 3 h / 100 °C

2: sodium tetrahydroborate / tetrahydrofuran; ethanol / 0.08 - 0.17 h / 20 °C

3: triethylamine / dichloromethane / 2 - 4 h / 0 °C

4: caesium carbonate / DMF (N,N-dimethyl-formamide) / 2 - 3 h / 20 °C

With sodium tetrahydroborate; sodium carbonate; caesium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); ethanol; dichloromethane; water; toluene;

Reference yield:

: 100124-06-9
4-dibenzofurylboronic acid

: 796071-10-8
(2R)-methyl-2-tert-butoxycarbonylamino-3-(4'-dibenzofuran-4-yl-biphenyl-4-ylmethylsulfanyl)-propionate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 2 - 3 h / 90 °C

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 2 - 3 h / 100 °C

3: sodium tetrahydroborate / tetrahydrofuran; ethanol / 0.08 - 0.17 h / 20 °C

4: triethylamine / dichloromethane / 2 - 4 h / 0 °C

5: caesium carbonate / DMF (N,N-dimethyl-formamide) / 2 - 3 h / 20 °C

With sodium tetrahydroborate; sodium carbonate; caesium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); ethanol; dichloromethane; water; toluene;