N-[N-(α-fluorenylmethoxycarbonyl)-(R)-phenylalanyl]-2(RS)-{2-[N-(N,N'-di-t-butoxycarbonylamidino)-4-piperidyloxy]ethyl}piperidine

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Chemical Name:N-[N-(α-fluorenylmethoxycarbonyl)-(R)-phenylalanyl]-2(RS)-{2-[N-(N,N'-di-t-butoxycarbonylamidino)-4-piperidyloxy]ethyl}piperidine
CAS No.:441771-91-1
Molecular Formula:C₄₇H₆₁N₅O₈
Molecular Weight:824.03
Hs Code.:

Synonyms:N-[N-(α-fluorenylmethoxycarbonyl)-(R)-phenylalanyl]-2(RS)-{2-[N-(N,N'-di-t-butoxycarbonylamidino)-4-piperidyloxy]ethyl}piperidine

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Chemical Property of N-[N-(α-fluorenylmethoxycarbonyl)-(R)-phenylalanyl]-2(RS)-{2-[N-(N,N'-di-t-butoxycarbonylamidino)-4-piperidyloxy]ethyl}piperidine

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Technology Process of N-[N-(α-fluorenylmethoxycarbonyl)-(R)-phenylalanyl]-2(RS)-{2-[N-(N,N'-di-t-butoxycarbonylamidino)-4-piperidyloxy]ethyl}piperidine

There total 9 articles about N-[N-(α-fluorenylmethoxycarbonyl)-(R)-phenylalanyl]-2(RS)-{2-[N-(N,N'-di-t-butoxycarbonylamidino)-4-piperidyloxy]ethyl}piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 86123-10-6
Fmoc-D-Phe-OH

: 190846-32-3
2(RS)-{2-[N-(N,N'-di-t-butoxycarbonylamidino)-4-piperidyloxy]ethyl}piperidine

: 441771-91-1
N-[N-(α-fluorenylmethoxycarbonyl)-(R)-phenylalanyl]-2(RS)-{2-[N-(N,N'-di-t-butoxycarbonylamidino)-4-piperidyloxy]ethyl}piperidine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In dichloromethane; at 0 ℃; for 4h;
DOI:10.1021/jm011133d

Reference yield:

: 1484-84-0
2(RS)-(2-hydroxyethyl)piperidine

: 441771-91-1
N-[N-(α-fluorenylmethoxycarbonyl)-(R)-phenylalanyl]-2(RS)-{2-[N-(N,N'-di-t-butoxycarbonylamidino)-4-piperidyloxy]ethyl}piperidine

Guidance literature:: Multi-step reaction with 7 steps

1.1: 43 percent / Et₃N / CH₂Cl₂ / 18 h / 23 °C

2.1: 84 percent / Et₃N / CH₂Cl₂ / 0.42 h / 17 °C

3.1: NaH / dimethylformamide / 2 h

3.2: 59 percent / dimethylformamide / 18 h

4.1: 100 percent / HCl(gas) / CH₂Cl₂ / 1.25 h / 0 °C

5.1: 78 percent / Et₃N; HgCl₂ / CH₂Cl₂ / 20 h

6.1: 99 percent / H₂ / 10percent Pd/C / ethanol / 2.5 h / 23 °C / 3102.97 Torr

7.1: 64 percent / DIPEA; bromotris(pyrrolidino)phosphonium hexafluorophosphate / CH₂Cl₂ / 4 h / 0 °C

With hydrogenchloride; hydrogen; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; mercury dichloride; 10percent Pd/C; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm011133d

Reference yield:

: 5382-16-1
4-HYDROXYPIPERIDINE

: 441771-91-1
N-[N-(α-fluorenylmethoxycarbonyl)-(R)-phenylalanyl]-2(RS)-{2-[N-(N,N'-di-t-butoxycarbonylamidino)-4-piperidyloxy]ethyl}piperidine

Guidance literature:: Multi-step reaction with 6 steps

1.1: 86 percent / CH₂Cl₂ / 56 h / 23 °C

2.1: NaH / dimethylformamide / 2 h

2.2: 59 percent / dimethylformamide / 18 h

3.1: 100 percent / HCl(gas) / CH₂Cl₂ / 1.25 h / 0 °C

4.1: 78 percent / Et₃N; HgCl₂ / CH₂Cl₂ / 20 h

5.1: 99 percent / H₂ / 10percent Pd/C / ethanol / 2.5 h / 23 °C / 3102.97 Torr

6.1: 64 percent / DIPEA; bromotris(pyrrolidino)phosphonium hexafluorophosphate / CH₂Cl₂ / 4 h / 0 °C

With hydrogenchloride; hydrogen; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; mercury dichloride; 10percent Pd/C; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm011133d