methyl 1-hydroxy-6-(3-(trifluoromethoxy)phenyl)-1H-indole-2-carboxylate

Base Information

Chemical Name:methyl 1-hydroxy-6-(3-(trifluoromethoxy)phenyl)-1H-indole-2-carboxylate
CAS No.:1303576-93-3
Molecular Formula:C₁₇H₁₂F₃NO₄
Molecular Weight:351.282
Hs Code.:

Synonyms:methyl 1-hydroxy-6-(3-(trifluoromethoxy)phenyl)-1H-indole-2-carboxylate

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Chemical Property of methyl 1-hydroxy-6-(3-(trifluoromethoxy)phenyl)-1H-indole-2-carboxylate

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Technology Process of methyl 1-hydroxy-6-(3-(trifluoromethoxy)phenyl)-1H-indole-2-carboxylate

There total 4 articles about methyl 1-hydroxy-6-(3-(trifluoromethoxy)phenyl)-1H-indole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1303575-30-5
C₁₇H₁₂F₃NO₆

: 1303576-93-3
methyl 1-hydroxy-6-(3-(trifluoromethoxy)phenyl)-1H-indole-2-carboxylate

Guidance literature:: C₁₇H₁₂F₃NO₆; With tin(II) chloride dihdyrate; thiophenol; triethylamine; In acetonitrile; at 20 ℃; for 0.0833333h;

With toluene-4-sulfonic acid; In toluene; Evaporation under vacuum;
DOI:10.1016/j.ejmech.2011.08.046

Reference yield:

: 1261766-95-3
4-methyl-3-nitro-3'-(trifluoromethoxy)biphenyl

: 1303576-93-3
methyl 1-hydroxy-6-(3-(trifluoromethoxy)phenyl)-1H-indole-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / -15 - 20 °C / Inert atmosphere

2.1: tin(II) chloride dihdyrate; thiophenol; triethylamine / acetonitrile / 0.08 h / 20 °C

2.2: Evaporation under vacuum

With tin(II) chloride dihdyrate; sodium hydride; thiophenol; triethylamine; In N,N-dimethyl-formamide; acetonitrile; mineral oil;
DOI:10.1016/j.ejmech.2011.08.046

Reference yield:

: 2252-44-0
1-bromo-3-(trifluoromethoxy)benzene

: 1303576-93-3
methyl 1-hydroxy-6-(3-(trifluoromethoxy)phenyl)-1H-indole-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrabutylammomium bromide; palladium diacetate; sodium carbonate / water / 0.08 h / 150 °C / Microwave irradiation; Sealed vessel

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / -15 - 20 °C / Inert atmosphere

3.1: tin(II) chloride dihdyrate; thiophenol; triethylamine / acetonitrile / 0.08 h / 20 °C

3.2: Evaporation under vacuum

With tin(II) chloride dihdyrate; tetrabutylammomium bromide; palladium diacetate; sodium hydride; sodium carbonate; thiophenol; triethylamine; In water; N,N-dimethyl-formamide; acetonitrile; mineral oil; 1.1: Suzuki coupling;
DOI:10.1016/j.ejmech.2011.08.046