3-[1-(benzenesulfonyl)-5-(morpholinomethyl)indol-2-yl]-3-oxo-propanenitrile

Base Information

Chemical Name:3-[1-(benzenesulfonyl)-5-(morpholinomethyl)indol-2-yl]-3-oxo-propanenitrile
CAS No.:1265234-02-3
Molecular Formula:C₂₂H₂₁N₃O₄S
Molecular Weight:423.492
Hs Code.:

Synonyms:3-[1-(benzenesulfonyl)-5-(morpholinomethyl)indol-2-yl]-3-oxo-propanenitrile

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Chemical Property of 3-[1-(benzenesulfonyl)-5-(morpholinomethyl)indol-2-yl]-3-oxo-propanenitrile

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Technology Process of 3-[1-(benzenesulfonyl)-5-(morpholinomethyl)indol-2-yl]-3-oxo-propanenitrile

There total 6 articles about 3-[1-(benzenesulfonyl)-5-(morpholinomethyl)indol-2-yl]-3-oxo-propanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: methyl 1-(benzenesulfonyl)-5-(morpholinomethyl)indole-2-carboxylate

: 75-05-8,26809-02-9
acetonitrile

: 1265234-02-3
3-[1-(benzenesulfonyl)-5-(morpholinomethyl)indol-2-yl]-3-oxo-propanenitrile

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.25h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.6b01156

Reference yield:

: methyl 1-(benzenesulfonyl)-5-formyl-indole-2-carboxylate

: 1265234-02-3
3-[1-(benzenesulfonyl)-5-(morpholinomethyl)indol-2-yl]-3-oxo-propanenitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid / dichloromethane / 0.17 h / 25 °C / Inert atmosphere

1.2: 2 h / 25 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

With acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;
DOI:10.1021/acs.jmedchem.6b01156

Reference yield:

: methyl 1-(benzenesulfonyl)-5-iodo-indole-2-carboxylate

: 1265234-02-3
3-[1-(benzenesulfonyl)-5-(morpholinomethyl)indol-2-yl]-3-oxo-propanenitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: TurboGrignard / tetrahydrofuran / -78 - -40 °C / Inert atmosphere

1.2: -78 - -20 °C / Inert atmosphere

2.1: acetic acid / dichloromethane / 0.17 h / 25 °C / Inert atmosphere

2.2: 2 h / 25 °C / Inert atmosphere

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

With TurboGrignard; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;
DOI:10.1021/acs.jmedchem.6b01156