ethyl (2E)-cyano({[(4-methylphenyl)sulfonyl]oxy}imino)acetate

Base Information

• Chemical Name: ethyl (2E)-cyano({[(4-methylphenyl)sulfonyl]oxy}imino)acetate
• CAS No.: 20992-37-4
• Molecular Formula: C₁₂H₁₂N₂O₅S
• Molecular Weight: 296.304
• Mol file: 20992-37-4.mol

Synonyms:ethyl (2E)-cyano({[(4-methylphenyl)sulfonyl]oxy}imino)acetate

Chemical Property of ethyl (2E)-cyano({[(4-methylphenyl)sulfonyl]oxy}imino)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of ethyl (2E)-cyano({[(4-methylphenyl)sulfonyl]oxy}imino)acetate

There total 3 articles about ethyl (2E)-cyano({[(4-methylphenyl)sulfonyl]oxy}imino)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

p-toluenesulfonyl chloride (98-59-9) + ethyl cyanoglyoxylate-2-oxime (3849-21-6) → ethyl (2E)-cyano({[(4-methylphenyl)sulfonyl]oxy}imino)acetate (20992-37-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 2.5h; Inert atmosphere;

DOI:10.1002/ejoc.201201571

Reference yield: 56.0%

ethyl (2E)-cyano(hydroxyimino)ethanoate (56503-39-0) + p-toluenesulfonyl chloride (98-59-9) → ethyl (2E)-cyano({[(4-methylphenyl)sulfonyl]oxy}imino)acetate (20992-37-4)

Guidance literature:

With pyridine; at -5 - 0 ℃; for 0.5h;

Reference yield:

ethyl 2-cyanoacetate (105-56-6) → ethyl (2E)-cyano({[(4-methylphenyl)sulfonyl]oxy}imino)acetate (20992-37-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / NaNO₂, H₂SO₄ / H₂O / 20 °C

2: 56 percent / pyridine / 0.5 h / -5 - 0 °C

With pyridine; sulfuric acid; sodium nitrite; In water;

upstream raw materials:

ethyl (2E)-cyano(hydroxyimino)ethanoate

p-toluenesulfonyl chloride

ethyl 2-cyanoacetate

ethyl cyanoglyoxylate-2-oxime

Downstream raw materials:

N-butyl-4-toluenesulfonamide

N-cyclohexyl-p-toluenesulfonamide

N-benzyl-p-toluenesulfonamide

N-(1-phenylethyl)-p-toluenesulfonamide