(+/-)-N-(1-azabicyclo[2.2.2]oct-3-yl)-4-methoxy-2-nitrobenzamide

Base Information

• Chemical Name: (+/-)-N-(1-azabicyclo[2.2.2]oct-3-yl)-4-methoxy-2-nitrobenzamide
• CAS No.: 1199793-62-8
• Molecular Formula: C₁₅H₁₉N₃O₄
• Molecular Weight: 305.334
• Mol file: 1199793-62-8.mol

Synonyms:(+/-)-N-(1-azabicyclo[2.2.2]oct-3-yl)-4-methoxy-2-nitrobenzamide

Chemical Property of (+/-)-N-(1-azabicyclo[2.2.2]oct-3-yl)-4-methoxy-2-nitrobenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-N-(1-azabicyclo[2.2.2]oct-3-yl)-4-methoxy-2-nitrobenzamide

There total 1 articles about (+/-)-N-(1-azabicyclo[2.2.2]oct-3-yl)-4-methoxy-2-nitrobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.1%

4-methoxy-2-nitro-benzoyl chloride (50424-96-9) + 3-aminoquinuclidine dihydrochloride (6530-09-2) → (+/-)-N-(1-azabicyclo[2.2.2]oct-3-yl)-4-methoxy-2-nitrobenzamide (1199793-62-8)

Guidance literature:

3-aminoquinuclidine dihydrochloride; With methanol; sodium methylate; for 0.166667h; Reflux;

4-methoxy-2-nitro-benzoyl chloride; In tetrahydrofuran; isopropyl alcohol; for 15h;

With sodium hydroxide; In tetrahydrofuran; water; isopropyl alcohol;

Reference yield: 43.0%

(+/-)-N-(1-azabicyclo[2.2.2]oct-3-yl)-4-methoxy-2-nitrobenzamide (1199793-62-8) → (+/-)-2-amino-N-(1-azabicyclo[2.2.2]oct-3-yl)-4-methoxybenzamide (1199793-59-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol;

upstream raw materials:

4-methoxy-2-nitro-benzoyl chloride

3-aminoquinuclidine dihydrochloride

Downstream raw materials:

(+/-)-2-amino-N-(1-azabicyclo[2.2.2]oct-3-yl)-4-methoxybenzamide