Technology Process of (2R,6S,7S,10R)-12-benzyloxy-1-tert-butyldimethylsilyloxy-2,6,10-trimethyldodecane-6,7-diol
There total 8 articles about (2R,6S,7S,10R)-12-benzyloxy-1-tert-butyldimethylsilyloxy-2,6,10-trimethyldodecane-6,7-diol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
methanesulfonamide; AD-mix-α;
In
water; tert-butyl alcohol;
at 0 ℃;
stereoselective reaction;
DOI:10.1016/j.tet.2011.09.066
- Guidance literature:
-
Multi-step reaction with 2 steps
1: disodium hydrogenphosphate; sodium-mercury amalgam (5%) / tetrahydrofuran; methanol / 1.5 h / -15 - 20 °C
2: AD-mix-α; methanesulfonamide / water; tert-butyl alcohol / 0 °C
With
disodium hydrogenphosphate; sodium-mercury amalgam (5%); methanesulfonamide; AD-mix-α;
In
tetrahydrofuran; methanol; water; tert-butyl alcohol;
2: Sharpless asymmetric dihydroxylation;
DOI:10.1016/j.tet.2011.09.066
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.33 h / -78 °C / Inert atmosphere
1.2: 1 h / -78 °C / Inert atmosphere
2.1: lithium bromide / tetrahydrofuran; hexane / 2 h / -78 - 20 °C / Inert atmosphere
3.1: N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium / tetrahydrofuran; hexane / -78 °C / Inert atmosphere
3.2: 0.67 h / -78 °C / Inert atmosphere
4.1: disodium hydrogenphosphate; sodium-mercury amalgam (5%) / tetrahydrofuran; methanol / 1.5 h / -15 - 20 °C
5.1: AD-mix-α; methanesulfonamide / water; tert-butyl alcohol / 0 °C
With
N,N,N,N,N,N-hexamethylphosphoric triamide; disodium hydrogenphosphate; sodium-mercury amalgam (5%); n-butyllithium; methanesulfonamide; AD-mix-α; lithium bromide;
In
tetrahydrofuran; methanol; hexane; water; tert-butyl alcohol;
5.1: Sharpless asymmetric dihydroxylation;
DOI:10.1016/j.tet.2011.09.066
