ethyl N-{7-[4-hydroxy-3-(1-hydroxy-2-phenylethyl)phenoxy]-6-methylindan-4-yl}malonamate

Base Information

Chemical Name:ethyl N-{7-[4-hydroxy-3-(1-hydroxy-2-phenylethyl)phenoxy]-6-methylindan-4-yl}malonamate
CAS No.:1427443-06-8
Molecular Formula:C₂₉H₃₁NO₆
Molecular Weight:489.568
Hs Code.:

Synonyms:ethyl N-{7-[4-hydroxy-3-(1-hydroxy-2-phenylethyl)phenoxy]-6-methylindan-4-yl}malonamate

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Chemical Property of ethyl N-{7-[4-hydroxy-3-(1-hydroxy-2-phenylethyl)phenoxy]-6-methylindan-4-yl}malonamate

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Technology Process of ethyl N-{7-[4-hydroxy-3-(1-hydroxy-2-phenylethyl)phenoxy]-6-methylindan-4-yl}malonamate

There total 3 articles about ethyl N-{7-[4-hydroxy-3-(1-hydroxy-2-phenylethyl)phenoxy]-6-methylindan-4-yl}malonamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1421015-72-6
ethyl N-[7-(4-hydroxy-3-phenylacetylphenoxy)-6-methylindan-4-yl]malonamate

: 1427443-06-8
ethyl N-{7-[4-hydroxy-3-(1-hydroxy-2-phenylethyl)phenoxy]-6-methylindan-4-yl}malonamate

Guidance literature:: With sodium tris(acetoxy)borohydride; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/j.bmc.2012.12.002

Reference yield:

: 575505-01-0
[7-(4-methoxyphenoxy)-6-methylindan-4-yl]amine

: 1427443-06-8
ethyl N-{7-[4-hydroxy-3-(1-hydroxy-2-phenylethyl)phenoxy]-6-methylindan-4-yl}malonamate

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / dichloromethane / 3 h / 20 °C

2: trifluoromethylsulfonic anhydride / dichloromethane / 15 h / 20 °C

3: boron trichloride / dichloromethane / 0 - 20 °C

4: sodium tris(acetoxy)borohydride / tetrahydrofuran / 20 °C

With pyridine; trifluoromethylsulfonic anhydride; boron trichloride; sodium tris(acetoxy)borohydride; In tetrahydrofuran; dichloromethane; 2: |Friedel-Crafts Acylation;
DOI:10.1016/j.bmc.2012.12.002

Reference yield:

: 575505-40-7
ethyl N-[7-(4-methoxyphenoxy)-6-methylindan-4-yl]malonamate

: 1427443-06-8
ethyl N-{7-[4-hydroxy-3-(1-hydroxy-2-phenylethyl)phenoxy]-6-methylindan-4-yl}malonamate

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoromethylsulfonic anhydride / dichloromethane / 15 h / 20 °C

2: boron trichloride / dichloromethane / 0 - 20 °C

3: sodium tris(acetoxy)borohydride / tetrahydrofuran / 20 °C

With trifluoromethylsulfonic anhydride; boron trichloride; sodium tris(acetoxy)borohydride; In tetrahydrofuran; dichloromethane; 1: |Friedel-Crafts Acylation;
DOI:10.1016/j.bmc.2012.12.002