N-[2-(4-aminomethyl-2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-yl]-pyrimidine-4,6-diamine hydrochloride salt

Base Information

Chemical Name:N-[2-(4-aminomethyl-2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-yl]-pyrimidine-4,6-diamine hydrochloride salt
CAS No.:1365990-63-1
Molecular Formula:C₁₇H₁₃Cl₂N₇S*ClH
Molecular Weight:454.77
Hs Code.:

Synonyms:N-[2-(4-aminomethyl-2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-yl]-pyrimidine-4,6-diamine hydrochloride salt

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Chemical Property of N-[2-(4-aminomethyl-2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-yl]-pyrimidine-4,6-diamine hydrochloride salt

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Technology Process of N-[2-(4-aminomethyl-2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-yl]-pyrimidine-4,6-diamine hydrochloride salt

There total 12 articles about N-[2-(4-aminomethyl-2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-yl]-pyrimidine-4,6-diamine hydrochloride salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1365992-39-7
C₂₇H₂₉Cl₂N₇O₄S

: 1365990-63-1
N-[2-(4-aminomethyl-2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-yl]-pyrimidine-4,6-diamine hydrochloride salt

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 45 ℃; for 3h; Inert atmosphere;

Reference yield:

: 628691-93-0
2-chloro-3-fluoro-pyridine-4-carboxylic acid

: 1365990-63-1
N-[2-(4-aminomethyl-2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-yl]-pyrimidine-4,6-diamine hydrochloride salt

Guidance literature:: Multi-step reaction with 11 steps

1.1: diphenyl phosphoryl azide / toluene / 3 h / 110 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

2.2: NH₂ cartridge

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h

3.2: 18 h

4.1: thionyl chloride / 18 h / Reflux

5.1: thiourea; pyridine / isopropyl alcohol / 16 h / Inert atmosphere; Reflux

5.2: 6.5 h / Reflux

6.1: trimethylsilyl bromide / propiononitrile / 48 h / 90 °C

7.1: potassium phosphate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene; water / 3 h / 80 °C / Inert atmosphere

8.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

9.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 1 h / 80 °C / Inert atmosphere

10.1: ammonia; sodium tetrahydroborate; cobalt(II) chloride hexahydrate / 0.25 h / 0 °C

11.1: hydrogenchloride / 1,4-dioxane / 3 h / 45 °C / Inert atmosphere

With pyridine; hydrogenchloride; sodium tetrahydroborate; potassium phosphate; thionyl chloride; cobalt(II) chloride hexahydrate; trimethylsilyl bromide; diphenyl phosphoryl azide; ammonia; sodium hydride; caesium carbonate; thiourea; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; isopropyl alcohol; toluene; propiononitrile; mineral oil;

Reference yield:

: 1258298-06-4
2,6-dichloro-4-cyanobenzoyl chloride

: 1365990-63-1
N-[2-(4-aminomethyl-2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-yl]-pyrimidine-4,6-diamine hydrochloride salt

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h

1.2: 18 h

2.1: thionyl chloride / 18 h / Reflux

3.1: thiourea; pyridine / isopropyl alcohol / 16 h / Inert atmosphere; Reflux

3.2: 6.5 h / Reflux

4.1: trimethylsilyl bromide / propiononitrile / 48 h / 90 °C

5.1: potassium phosphate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene; water / 3 h / 80 °C / Inert atmosphere

6.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

7.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 1 h / 80 °C / Inert atmosphere

8.1: ammonia; sodium tetrahydroborate; cobalt(II) chloride hexahydrate / 0.25 h / 0 °C

9.1: hydrogenchloride / 1,4-dioxane / 3 h / 45 °C / Inert atmosphere

With pyridine; hydrogenchloride; sodium tetrahydroborate; potassium phosphate; thionyl chloride; cobalt(II) chloride hexahydrate; trimethylsilyl bromide; ammonia; sodium hydride; caesium carbonate; thiourea; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; isopropyl alcohol; toluene; propiononitrile; mineral oil;