(Z)-4-{(2R,6R)-6-[(S)-5-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-pentyl]-5,6-dihydro-2H-pyran-2-yl}-but-2-enoic acid methyl ester

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Chemical Name:(Z)-4-{(2R,6R)-6-[(S)-5-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-pentyl]-5,6-dihydro-2H-pyran-2-yl}-but-2-enoic acid methyl ester
CAS No.:334936-12-8
Molecular Formula:C₃₂H₄₄O₄Si
Molecular Weight:520.784
Hs Code.:

Synonyms:(Z)-4-{(2R,6R)-6-[(S)-5-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-pentyl]-5,6-dihydro-2H-pyran-2-yl}-but-2-enoic acid methyl ester

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Chemical Property of (Z)-4-{(2R,6R)-6-[(S)-5-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-pentyl]-5,6-dihydro-2H-pyran-2-yl}-but-2-enoic acid methyl ester

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Technology Process of (Z)-4-{(2R,6R)-6-[(S)-5-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-pentyl]-5,6-dihydro-2H-pyran-2-yl}-but-2-enoic acid methyl ester

There total 12 articles about (Z)-4-{(2R,6R)-6-[(S)-5-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-pentyl]-5,6-dihydro-2H-pyran-2-yl}-but-2-enoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 88738-78-7
bis-(2,2,2-trifluoroethyl)(methoxycarbonylmethyl)phosphonate

: 334936-03-7
{6-[5-(tert-butyl-diphenyl-silanyloxy)-2-methyl-pentyl]-5,6-dihydro-2H-pyran-2-yl}-acetaldehyde

: 334936-12-8
(Z)-4-{(2R,6R)-6-[(S)-5-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-pentyl]-5,6-dihydro-2H-pyran-2-yl}-but-2-enoic acid methyl ester

Guidance literature:: With 18-crown-6 ether; potassium hexamethylsilazane; In tetrahydrofuran; at -78 ℃;
DOI:10.1016/S0040-4039(00)02116-X

Reference yield:

: 5949-05-3
(S)-Citronellal

: 334936-12-8
(Z)-4-{(2R,6R)-6-[(S)-5-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-pentyl]-5,6-dihydro-2H-pyran-2-yl}-but-2-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: 80 percent / PDC / dimethylformamide / 20 °C

2.1: ozone / methanol / -78 °C

2.2: 82 percent / NaBH₄

3.1: 89 percent / DMAP; imidazole / dimethylformamide / 10 h / 20 °C

4.1: 85 percent / DIBAL / CH₂Cl₂ / 1.5 h / -78 °C

5.1: 80 percent / (S)-BINOL; Ti(Oi-Pr)4

6.1: 83 percent / Pd(OAc)2 / acetonitrile / 20 h / Heating

7.1: 85 percent / Cl₂(PCy₃)2Ru=CHPh / CH₂Cl₂ / 36 h / 20 °C

8.1: 78 percent / EtOAc; LiClO₄

9.1: 83 percent / KHMDS; 18-crown-6 / tetrahydrofuran / -78 °C

With 1H-imidazole; titanium(IV) isopropylate; dmap; palladium diacetate; dipyridinium dichromate; Grubbs catalyst first generation; 18-crown-6 ether; (S)-[1,1']-binaphthalenyl-2,2'-diol; lithium perchlorate; potassium hexamethylsilazane; diisobutylaluminium hydride; ozone; ethyl acetate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 8.1: Ferrier rearrangement;
DOI:10.1016/S0040-4039(00)02116-X

Reference yield:

: 56994-89-9
(S)-(-)-citronellic acid,methyl ester

: 334936-12-8
(Z)-4-{(2R,6R)-6-[(S)-5-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-pentyl]-5,6-dihydro-2H-pyran-2-yl}-but-2-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: ozone / methanol / -78 °C

1.2: 82 percent / NaBH₄

2.1: 89 percent / DMAP; imidazole / dimethylformamide / 10 h / 20 °C

3.1: 85 percent / DIBAL / CH₂Cl₂ / 1.5 h / -78 °C

4.1: 80 percent / (S)-BINOL; Ti(Oi-Pr)4

5.1: 83 percent / Pd(OAc)2 / acetonitrile / 20 h / Heating

6.1: 85 percent / Cl₂(PCy₃)2Ru=CHPh / CH₂Cl₂ / 36 h / 20 °C

7.1: 78 percent / EtOAc; LiClO₄

8.1: 83 percent / KHMDS; 18-crown-6 / tetrahydrofuran / -78 °C

With 1H-imidazole; titanium(IV) isopropylate; dmap; palladium diacetate; Grubbs catalyst first generation; 18-crown-6 ether; (S)-[1,1']-binaphthalenyl-2,2'-diol; lithium perchlorate; potassium hexamethylsilazane; diisobutylaluminium hydride; ozone; ethyl acetate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 7.1: Ferrier rearrangement;
DOI:10.1016/S0040-4039(00)02116-X