methyl 3-[4-(3-{3-benzyloxy-1-[5-(trifluoromethyl)-2-pyridyl]-1H-pyrazol-4-yl}propoxy)-2-ethoxyphenyl]propanoate

Base Information

Chemical Name:methyl 3-[4-(3-{3-benzyloxy-1-[5-(trifluoromethyl)-2-pyridyl]-1H-pyrazol-4-yl}propoxy)-2-ethoxyphenyl]propanoate
CAS No.:628334-45-2
Molecular Formula:C₃₁H₃₂F₃N₃O₅
Molecular Weight:583.607
Hs Code.:

Synonyms:methyl 3-[4-(3-{3-benzyloxy-1-[5-(trifluoromethyl)-2-pyridyl]-1H-pyrazol-4-yl}propoxy)-2-ethoxyphenyl]propanoate

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Chemical Property of methyl 3-[4-(3-{3-benzyloxy-1-[5-(trifluoromethyl)-2-pyridyl]-1H-pyrazol-4-yl}propoxy)-2-ethoxyphenyl]propanoate

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Technology Process of methyl 3-[4-(3-{3-benzyloxy-1-[5-(trifluoromethyl)-2-pyridyl]-1H-pyrazol-4-yl}propoxy)-2-ethoxyphenyl]propanoate

There total 6 articles about methyl 3-[4-(3-{3-benzyloxy-1-[5-(trifluoromethyl)-2-pyridyl]-1H-pyrazol-4-yl}propoxy)-2-ethoxyphenyl]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-51-6,185532-71-2
benzyl alcohol

: 628334-45-2
methyl 3-[4-(3-{3-benzyloxy-1-[5-(trifluoromethyl)-2-pyridyl]-1H-pyrazol-4-yl}propoxy)-2-ethoxyphenyl]propanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / tetrahydrofuran / 20 °C

1.2: 20 °C

2.1: hydrogenchloride / ethyl acetate

3.1: sodium hydride / DMF (N,N-dimethyl-formamide) / 1 h / 20 °C

4.1: diisobutylaluminium hydride / tetrahydrofuran; hexane / 3 h / 0 - 20 °C

5.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C

With hydrogenchloride; di-isopropyl azodicarboxylate; sodium hydride; diisobutylaluminium hydride; triethylamine; triphenylphosphine; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); hexane; ethyl acetate;

Reference yield:

: ethyl 3-{3-benzyloxy-1-[5-(trifluoromethyl)-2-pyridinyl]-1H-pyrazol-4-yl}propanoate

: 628334-45-2
methyl 3-[4-(3-{3-benzyloxy-1-[5-(trifluoromethyl)-2-pyridyl]-1H-pyrazol-4-yl}propoxy)-2-ethoxyphenyl]propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: diisobutylaluminium hydride / tetrahydrofuran; hexane / 3 h / 0 - 20 °C

2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C

With di-isopropyl azodicarboxylate; diisobutylaluminium hydride; triphenylphosphine; In tetrahydrofuran; hexane;

Reference yield:

: 526197-44-4
ethyl 3-(3-hydroxy-1H-pyrazol-4-yl)propionate

: 628334-45-2
methyl 3-[4-(3-{3-benzyloxy-1-[5-(trifluoromethyl)-2-pyridyl]-1H-pyrazol-4-yl}propoxy)-2-ethoxyphenyl]propanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / tetrahydrofuran / 20 °C

1.2: 20 °C

2.1: hydrogenchloride / ethyl acetate

3.1: sodium hydride / DMF (N,N-dimethyl-formamide) / 1 h / 20 °C

4.1: diisobutylaluminium hydride / tetrahydrofuran; hexane / 3 h / 0 - 20 °C

5.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C

With hydrogenchloride; di-isopropyl azodicarboxylate; sodium hydride; diisobutylaluminium hydride; triethylamine; triphenylphosphine; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); hexane; ethyl acetate;