trichloroethyl (1S,6R,7R)-3-methyl-4-(3'-oxobutyl)-7β-phenoxyacetamidoceph-2-em-4-carboxylate 1-oxide

Base Information

Chemical Name:trichloroethyl (1S,6R,7R)-3-methyl-4-(3'-oxobutyl)-7β-phenoxyacetamidoceph-2-em-4-carboxylate 1-oxide
CAS No.:134830-12-9
Molecular Formula:C₂₂H₂₃Cl₃N₂O₇S
Molecular Weight:565.859
Hs Code.:

Synonyms:trichloroethyl (1S,6R,7R)-3-methyl-4-(3'-oxobutyl)-7β-phenoxyacetamidoceph-2-em-4-carboxylate 1-oxide

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Chemical Property of trichloroethyl (1S,6R,7R)-3-methyl-4-(3'-oxobutyl)-7β-phenoxyacetamidoceph-2-em-4-carboxylate 1-oxide

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Technology Process of trichloroethyl (1S,6R,7R)-3-methyl-4-(3'-oxobutyl)-7β-phenoxyacetamidoceph-2-em-4-carboxylate 1-oxide

There total 2 articles about trichloroethyl (1S,6R,7R)-3-methyl-4-(3'-oxobutyl)-7β-phenoxyacetamidoceph-2-em-4-carboxylate 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 134454-79-8
trichloroethyl (6R,7R)-3-methyl-4-(3'-oxobutyl)-7β-phenoxyacetamidoceph-2-em-4-carboxylate

: 134830-12-9
trichloroethyl (1S,6R,7R)-3-methyl-4-(3'-oxobutyl)-7β-phenoxyacetamidoceph-2-em-4-carboxylate 1-oxide

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 0.5h;

Reference yield:

: 24647-47-0
2,2,2-Trichloroethyl (6R,7R)-3-methyl-<(phenoxyacetyl)amino>-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylate

: 134830-12-9
trichloroethyl (1S,6R,7R)-3-methyl-4-(3'-oxobutyl)-7β-phenoxyacetamidoceph-2-em-4-carboxylate 1-oxide

Guidance literature:: Multi-step reaction with 2 steps

1: 51 percent / Et₃N / 18 h / Ambient temperature

2: 85 percent / m-CPBA / CH₂Cl₂ / 0.5 h / 0 °C

With triethylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;

Reference yield:

: 134830-12-9
trichloroethyl (1S,6R,7R)-3-methyl-4-(3'-oxobutyl)-7β-phenoxyacetamidoceph-2-em-4-carboxylate 1-oxide

: 121406-66-4
(6R,7R)-3-methyl-4-(3'-oxobutyl)-7β-phenoxyacetamidoceph-3-em

Guidance literature:: Multi-step reaction with 2 steps

1: 1) glacial acetic acid, zinc powder, 2) aq. NaHCO₃ / 1) DMF, 1 h, r.t., 2) ethyl acetate

2: 73 percent / pyridine, P₂S₅ / CH₂Cl₂ / 2 h / Ambient temperature

With pyridine; tetraphosphorus decasulfide; sodium hydrogencarbonate; acetic acid; zinc; In dichloromethane;