{(2R,4aR,6S,7R,8aS)-6-[(6R,7S)-6-Benzyloxy-7-(3-benzyloxy-propyl)-7-methyl-4,5,6,7-tetrahydro-oxepin-2-ylmethyl]-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yloxy}-triethyl-silane

Base Information

Chemical Name:{(2R,4aR,6S,7R,8aS)-6-[(6R,7S)-6-Benzyloxy-7-(3-benzyloxy-propyl)-7-methyl-4,5,6,7-tetrahydro-oxepin-2-ylmethyl]-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yloxy}-triethyl-silane
CAS No.:850656-56-3
Molecular Formula:C₄₄H₆₀O₇Si
Molecular Weight:729.042
Hs Code.:

{(2R,4aR,6S,7R,8aS)-6-[(6R,7S)-6-Benzyloxy-7-(3-benzyloxy-propyl)-7-methyl-4,5,6,7-tetrahydro-oxepin-2-ylmethyl]-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yloxy}-triethyl-silane

Synonyms:{(2R,4aR,6S,7R,8aS)-6-[(6R,7S)-6-Benzyloxy-7-(3-benzyloxy-propyl)-7-methyl-4,5,6,7-tetrahydro-oxepin-2-ylmethyl]-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yloxy}-triethyl-silane

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Chemical Property of {(2R,4aR,6S,7R,8aS)-6-[(6R,7S)-6-Benzyloxy-7-(3-benzyloxy-propyl)-7-methyl-4,5,6,7-tetrahydro-oxepin-2-ylmethyl]-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yloxy}-triethyl-silane

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Technology Process of {(2R,4aR,6S,7R,8aS)-6-[(6R,7S)-6-Benzyloxy-7-(3-benzyloxy-propyl)-7-methyl-4,5,6,7-tetrahydro-oxepin-2-ylmethyl]-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yloxy}-triethyl-silane

There total 25 articles about {(2R,4aR,6S,7R,8aS)-6-[(6R,7S)-6-Benzyloxy-7-(3-benzyloxy-propyl)-7-methyl-4,5,6,7-tetrahydro-oxepin-2-ylmethyl]-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yloxy}-triethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 850656-50-7
Triethyl-((2R,4aR,7R,8aS)-6-methylene-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yloxy)-silane

: 436153-54-7
Phosphoric acid (6R,7S)-6-benzyloxy-7-(3-benzyloxy-propyl)-7-methyl-4,5,6,7-tetrahydro-oxepin-2-yl ester diphenyl ester

: 850656-56-3
{(2R,4aR,6S,7R,8aS)-6-[(6R,7S)-6-Benzyloxy-7-(3-benzyloxy-propyl)-7-methyl-4,5,6,7-tetrahydro-oxepin-2-ylmethyl]-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yloxy}-triethyl-silane

Guidance literature:: Triethyl-((2R,4aR,7R,8aS)-6-methylene-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yloxy)-silane; With 9-borabicyclo[3.3.1]nonane dimer; In tetrahydrofuran; at 20 ℃; for 2h;

Phosphoric acid (6R,7S)-6-benzyloxy-7-(3-benzyloxy-propyl)-7-methyl-4,5,6,7-tetrahydro-oxepin-2-yl ester diphenyl ester; With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; at 50 ℃; for 13.5h;
DOI:10.1021/ja042686r

Reference yield:

: 850656-53-0
(4R,5S)-1-[1,3]Dioxan-2-yl-5-methoxymethoxy-5,9-dimethyl-dec-8-en-4-ol

: 850656-56-3
{(2R,4aR,6S,7R,8aS)-6-[(6R,7S)-6-Benzyloxy-7-(3-benzyloxy-propyl)-7-methyl-4,5,6,7-tetrahydro-oxepin-2-ylmethyl]-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yloxy}-triethyl-silane

Guidance literature:: Multi-step reaction with 8 steps

1.1: 13.39 g / potassium t-butoxide / tetrahydrofuran / 0 - 20 °C

2.1: O₃ / CH₂Cl₂; methanol / 0.58 h / -78 °C

2.2: 90 percent / NaBH₄ / CH₂Cl₂; methanol / -78 - 0 °C

3.1: potassium t-butoxide / tetrahydrofuran / 0 - 20 °C

4.1: aq. HCl / tetrahydrofuran / 8 h / 70 °C

5.1: aq. NaClO₂; NaH₂PO₄; 2-methyl-2-butene / 2-methyl-propan-2-ol / 2 h / 20 °C

6.1: 2,4,6-trichlorobenzoyl chloride; Et₃N / tetrahydrofuran / 2 h / 20 °C

6.2: 62 percent / DMAP / toluene; tetrahydrofuran / Heating

7.1: KHMDS; hexamethylphosphoramide / tetrahydrofuran; toluene / 0.75 h / -78 °C

8.1: 9-BBN / tetrahydrofuran / 2 h / 20 °C

8.2: 15.73 g / PdCl₂(dppf)*CH₂Cl₂; aq. Cs₂CO₃ / dimethylformamide; tetrahydrofuran / 13.5 h / 50 °C

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium chlorite; sodium dihydrogenphosphate; 9-borabicyclo[3.3.1]nonane dimer; 2-methyl-but-2-ene; 2,4,6-trichlorobenzoyl chloride; potassium tert-butylate; potassium hexamethylsilazane; ozone; triethylamine; In tetrahydrofuran; methanol; dichloromethane; toluene; tert-butyl alcohol; 8.2: Suzuki-Miyaura cross-coupling;
DOI:10.1021/ja042686r

Reference yield:

: (5R,6S)-5,9-Bis-benzyloxy-6-methoxymethoxy-6-methyl-nonanal

: 850656-56-3
{(2R,4aR,6S,7R,8aS)-6-[(6R,7S)-6-Benzyloxy-7-(3-benzyloxy-propyl)-7-methyl-4,5,6,7-tetrahydro-oxepin-2-ylmethyl]-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yloxy}-triethyl-silane

Guidance literature:: Multi-step reaction with 4 steps

1.1: aq. NaClO₂; NaH₂PO₄; 2-methyl-2-butene / 2-methyl-propan-2-ol / 2 h / 20 °C

2.1: 2,4,6-trichlorobenzoyl chloride; Et₃N / tetrahydrofuran / 2 h / 20 °C

2.2: 62 percent / DMAP / toluene; tetrahydrofuran / Heating

3.1: KHMDS; hexamethylphosphoramide / tetrahydrofuran; toluene / 0.75 h / -78 °C

4.1: 9-BBN / tetrahydrofuran / 2 h / 20 °C

4.2: 15.73 g / PdCl₂(dppf)*CH₂Cl₂; aq. Cs₂CO₃ / dimethylformamide; tetrahydrofuran / 13.5 h / 50 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium chlorite; sodium dihydrogenphosphate; 9-borabicyclo[3.3.1]nonane dimer; 2-methyl-but-2-ene; 2,4,6-trichlorobenzoyl chloride; potassium hexamethylsilazane; triethylamine; In tetrahydrofuran; toluene; tert-butyl alcohol; 4.2: Suzuki-Miyaura cross-coupling;
DOI:10.1021/ja042686r