ethyl 1-hydroxy-2-oxo-3H-pyrrolo[3,2-b]pyridine-3-carboxylate

Base Information

Chemical Name:ethyl 1-hydroxy-2-oxo-3H-pyrrolo[3,2-b]pyridine-3-carboxylate
CAS No.:87592-15-2
Molecular Formula:C₁₀H₁₀N₂O₄
Molecular Weight:222.2
Hs Code.:
NSC Number:244255
DSSTox Substance ID:DTXSID30311595

Synonyms:87592-15-2;NSC 244255;ethyl 1-hydroxy-2-oxo-2,3-dihydro-1h-pyrrolo[3,2-b]pyridine-3-carboxylate;NSC244255;ethyl 1-hydroxy-2-oxo-3H-pyrrolo[3,2-b]pyridine-3-carboxylate;DTXSID30311595;NSC-244255

Suppliers and Price of ethyl 1-hydroxy-2-oxo-3H-pyrrolo[3,2-b]pyridine-3-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 2 raw suppliers

Chemical Property of ethyl 1-hydroxy-2-oxo-3H-pyrrolo[3,2-b]pyridine-3-carboxylate

Chemical Property:

Vapor Pressure:3.23E-06mmHg at 25°C
Boiling Point:372.7°Cat760mmHg
Flash Point:179.2°C
Density:1.477g/cm³
XLogP3:-0.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:222.06405680
Heavy Atom Count:16
Complexity:307

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1C2=C(C=CC=N2)N(C1=O)O

Technology Process of ethyl 1-hydroxy-2-oxo-3H-pyrrolo[3,2-b]pyridine-3-carboxylate

There total 3 articles about ethyl 1-hydroxy-2-oxo-3H-pyrrolo[3,2-b]pyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 64362-41-0
diethyl 2-(3-nitropyridin-2-yl)malonate

: 87592-15-2
3-ethoxycarbonyl-1-hydroxy-4-azaindol-2(3H)-one

Guidance literature:: With zinc; In acetic acid; 1.) 15 deg C, 1.5 h; 2.) rooom temperature, 6 h;

Reference yield: 7.0%

: 87592-13-0
ethyl 2-amino-1-hydroxy-4-azaindole-3-carboxylate

: 87592-15-2
3-ethoxycarbonyl-1-hydroxy-4-azaindol-2(3H)-one

Guidance literature:: With sodium nitrite; In sulfuric acid; 1.) 0 deg C, 0.5 h; 2.) room temperature, overnight;

Reference yield:

: 5236-72-6
ethyl 2-cyano-2-(3-nitropyridin-2-yl)acetate

: 87592-15-2
3-ethoxycarbonyl-1-hydroxy-4-azaindol-2(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: 15 percent / H₂ / 10percent Pd/C / ethanol / 2 h / Ambient temperature

2: 7 percent / aq. NaNO₂ / aq. H₂SO₄ / 1.) 0 deg C, 0.5 h; 2.) room temperature, overnight

With hydrogen; sodium nitrite; palladium on activated charcoal; In ethanol; sulfuric acid;