(S)-1-(3-bromo-2-(4-methoxyphenyl)propyl)-2,4-dimethoxy-benzene

Base Information

• Chemical Name: (S)-1-(3-bromo-2-(4-methoxyphenyl)propyl)-2,4-dimethoxy-benzene
• CAS No.: 1057663-20-3
• Molecular Formula: C₁₈H₂₁BrO₃
• Molecular Weight: 365.267
• Mol file: 1057663-20-3.mol

Synonyms:(S)-1-(3-bromo-2-(4-methoxyphenyl)propyl)-2,4-dimethoxy-benzene

Chemical Property of (S)-1-(3-bromo-2-(4-methoxyphenyl)propyl)-2,4-dimethoxy-benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-1-(3-bromo-2-(4-methoxyphenyl)propyl)-2,4-dimethoxy-benzene

There total 8 articles about (S)-1-(3-bromo-2-(4-methoxyphenyl)propyl)-2,4-dimethoxy-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(S)-3-(2,4-dimethoxyphenyl)-2-(4-methoxyphenyl)propan-1-ol (1057663-19-0) → (S)-1-(3-bromo-2-(4-methoxyphenyl)propyl)-2,4-dimethoxy-benzene (1057663-20-3)

Guidance literature:

With carbon tetrabromide; triphenylphosphine;

DOI:10.1016/j.tetlet.2008.06.085

Reference yield:

C18H20O4 → (S)-1-(3-bromo-2-(4-methoxyphenyl)propyl)-2,4-dimethoxy-benzene (1057663-20-3)

Guidance literature:

C₁₈H₂₀O₄; With sodium tetrahydroborate; In methanol; diethyl ether; dichloromethane; toluene; at 23 ℃; for 1h;

With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 0 - 20 ℃; for 3h;

DOI:10.1055/a-1303-9935

Reference yield:

2,4-Dimethoxybenzaldehyde (613-45-6) → (S)-1-(3-bromo-2-(4-methoxyphenyl)propyl)-2,4-dimethoxy-benzene (1057663-20-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: acetic anhydride; triethylamine / 2 h / Reflux

2.1: C₅₆H₇₂IrNOP; hydrogen; triethylamine / methanol / 72 h / 70 °C / 9120.61 Torr

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 2.25 h / 0 - 20 °C

3.2: 0 °C

4.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 3 h / 20 °C / Cooling with ice

With lithium aluminium tetrahydride; carbon tetrabromide; C₅₆H₇₂IrNOP; hydrogen; acetic anhydride; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1016/j.tet.2012.03.118

upstream raw materials:

(S)-3-(2,4-dimethoxyphenyl)-2-(4-methoxyphenyl)propan-1-ol

4-Methoxyphenylacetic acid

(E)-3-(2,4-dimethoxyphenyl)-2-(4-methoxyphenyl)acrylic acid

2,4-Dimethoxybenzaldehyde

Downstream raw materials:

(S)-4-(3-bromo-2-(4-hydroxyphenyl)propyl)benzene-1,3-diol

equol