(S)-3-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-[3-(2-methoxy-phenyl)-ureido]-hexanoylamino}-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid

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Chemical Name:(S)-3-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-[3-(2-methoxy-phenyl)-ureido]-hexanoylamino}-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid
CAS No.:130408-76-3
Molecular Formula:C₄₃H₅₄N₈O₁₀
Molecular Weight:842.949
Hs Code.:

(S)-3-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-[3-(2-methoxy-phenyl)-ureido]-hexanoylamino}-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid

Synonyms:(S)-3-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-[3-(2-methoxy-phenyl)-ureido]-hexanoylamino}-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid

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Chemical Property of (S)-3-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-[3-(2-methoxy-phenyl)-ureido]-hexanoylamino}-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid

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Technology Process of (S)-3-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-[3-(2-methoxy-phenyl)-ureido]-hexanoylamino}-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid

There total 4 articles about (S)-3-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-[3-(2-methoxy-phenyl)-ureido]-hexanoylamino}-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3392-11-8
2,5-dioxopyrrolidin-1-yl N-(tert-butoxycarbonyl)-L-tryptophanate

: 130408-76-3
(S)-3-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-[3-(2-methoxy-phenyl)-ureido]-hexanoylamino}-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 11.9 g / N-methylmorpholine / dimethylformamide / 18 h / 0 - 20 °C

2: 3.95 g / H₂ / 10percent Pd/C / 18 h / 760 Torr / Ambient temperature

3: N-methylmorpholine / dimethylformamide / 18 h / Ambient temperature

With 4-methyl-morpholine; hydrogen; palladium on activated charcoal; In N,N-dimethyl-formamide;
DOI:10.1021/jm960509y

Reference yield:

: 131450-40-3
H-Lys(CBz)-Asp(OBn)-Phe-NH₂ hydrochloride

: 130408-76-3
(S)-3-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-[3-(2-methoxy-phenyl)-ureido]-hexanoylamino}-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 11.9 g / N-methylmorpholine / dimethylformamide / 18 h / 0 - 20 °C

2: 3.95 g / H₂ / 10percent Pd/C / 18 h / 760 Torr / Ambient temperature

3: N-methylmorpholine / dimethylformamide / 18 h / Ambient temperature

With 4-methyl-morpholine; hydrogen; palladium on activated charcoal; In N,N-dimethyl-formamide;
DOI:10.1021/jm960509y

Reference yield:

: 131450-41-4
(S)-3-{(S)-6-Benzyloxycarbonylamino-2-[(S)-2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-hexanoylamino}-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid benzyl ester

: 130408-76-3
(S)-3-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-[3-(2-methoxy-phenyl)-ureido]-hexanoylamino}-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 3.95 g / H₂ / 10percent Pd/C / 18 h / 760 Torr / Ambient temperature

2: N-methylmorpholine / dimethylformamide / 18 h / Ambient temperature

With 4-methyl-morpholine; hydrogen; palladium on activated charcoal; In N,N-dimethyl-formamide;
DOI:10.1021/jm960509y