N-(4-(4-(4-fluorobenzyl)piperazine-1-carbonyl)phenyl)quinoline-8-sulfonamide-(D)

Base Information

Chemical Name:N-(4-(4-(4-fluorobenzyl)piperazine-1-carbonyl)phenyl)quinoline-8-sulfonamide-(D)
CAS No.:1384445-20-8
Molecular Formula:C₂₇H₂₅FN₄O₃S
Molecular Weight:505.577
Hs Code.:

Synonyms:N-(4-(4-(4-fluorobenzyl)piperazine-1-carbonyl)phenyl)quinoline-8-sulfonamide-(D)

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Chemical Property of N-(4-(4-(4-fluorobenzyl)piperazine-1-carbonyl)phenyl)quinoline-8-sulfonamide-(D)

Chemical Property:

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Technology Process of N-(4-(4-(4-fluorobenzyl)piperazine-1-carbonyl)phenyl)quinoline-8-sulfonamide-(D)

There total 7 articles about N-(4-(4-(4-fluorobenzyl)piperazine-1-carbonyl)phenyl)quinoline-8-sulfonamide-(D) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1260081-87-5
N-(4-(piperazine-1-carbonyl)phenyl)quinoline-8-sulfonamide

: 459-57-4
4-fluorobenzaldehyde

: 1384445-20-8
N-(4-(4-(4-fluorobenzyl)piperazine-1-carbonyl)phenyl)quinoline-8-sulfonamide-(D)

Guidance literature:: N-(4-(piperazine-1-carbonyl)phenyl)quinoline-8-sulfonamide; 4-fluorobenzaldehyde; With acetic acid; In dichloromethane; at 20 ℃; for 0.5h;

With sodium borodeuteride; In dichloromethane; at 50 ℃; for 2h;

Reference yield:

: 18704-37-5
quinoline-8-sulfonyl chloride

: 1384445-20-8
N-(4-(4-(4-fluorobenzyl)piperazine-1-carbonyl)phenyl)quinoline-8-sulfonamide-(D)

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / dichloromethane / 16 h / 20 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere

3.1: hydrogenchloride / methanol / 1 h

4.1: acetic acid / dichloromethane / 0.5 h / 20 °C

4.2: 2 h / 50 °C

With pyridine; hydrogenchloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 150-13-0,159246-81-8,8014-65-1
4-amino-benzoic acid

: 1384445-20-8
N-(4-(4-(4-fluorobenzyl)piperazine-1-carbonyl)phenyl)quinoline-8-sulfonamide-(D)

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / dichloromethane / 16 h / 20 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere

3.1: hydrogenchloride / methanol / 1 h

4.1: acetic acid / dichloromethane / 0.5 h / 20 °C

4.2: 2 h / 50 °C

With pyridine; hydrogenchloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;