6-({[4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl]methoxy}methyl)-4-hydroxy-2-(methylthio)pyrimidine

Base Information

Chemical Name:6-({[4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl]methoxy}methyl)-4-hydroxy-2-(methylthio)pyrimidine
CAS No.:101988-81-2
Molecular Formula:C₂₄H₂₅Cl₂N₃O₆S
Molecular Weight:554.451
Hs Code.:

6-({[4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl]methoxy}methyl)-4-hydroxy-2-(methylthio)pyrimidine

Synonyms:6-({[4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl]methoxy}methyl)-4-hydroxy-2-(methylthio)pyrimidine

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Chemical Property of 6-({[4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl]methoxy}methyl)-4-hydroxy-2-(methylthio)pyrimidine

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Technology Process of 6-({[4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl]methoxy}methyl)-4-hydroxy-2-(methylthio)pyrimidine

There total 10 articles about 6-({[4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl]methoxy}methyl)-4-hydroxy-2-(methylthio)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 867-44-7,147895-43-0
S-Methylisothiourea sulfate

: 97290-03-4
ethyl 4-<<4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl>methoxy>acetoacetate

: 101988-81-2
6-({[4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl]methoxy}methyl)-4-hydroxy-2-(methylthio)pyrimidine

Guidance literature:: With 2,6-dichloro-benzonitrile; In ethanol; for 120h;
DOI:10.1021/jm00130a026

Reference yield:

: 638-07-3
ethyl (2-chloroaceto)acetate

: 101988-81-2
6-({[4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl]methoxy}methyl)-4-hydroxy-2-(methylthio)pyrimidine

Guidance literature:: Multi-step reaction with 6 steps

1: 1) NaH / 1) THF, oil, ice cooling, 2) THF, 16 h

2: 1) piperidine / 1) 2-propanol, 24 h, 2) 4 d

3: 1) nBuLi / 1) hexane, THF, -65 deg C, 2.5 h, 2) 2 h, to 0 deg C

4: 1) Triton B / dimethylsulfoxide

5: 1) Et₂NH, 2) H₂O, AcOH / 1) THF, 1.5 h, 2) 6 h

6: 48 percent / DBN / ethanol / 120 h

With piperidine; n-butyllithium; 2,6-dichloro-benzonitrile; water; N-benzyl-trimethylammonium hydroxide; sodium hydride; acetic acid; diethylamine; In ethanol; dimethyl sulfoxide;
DOI:10.1021/jm00130a026

Reference yield:

: 101411-65-8
1-<<4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl>methoxy>-2-propyne

: 101988-81-2
6-({[4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl]methoxy}methyl)-4-hydroxy-2-(methylthio)pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1: 1) nBuLi / 1) hexane, THF, -65 deg C, 2.5 h, 2) 2 h, to 0 deg C

2: 1) Triton B / dimethylsulfoxide

3: 1) Et₂NH, 2) H₂O, AcOH / 1) THF, 1.5 h, 2) 6 h

4: 48 percent / DBN / ethanol / 120 h

With n-butyllithium; 2,6-dichloro-benzonitrile; water; N-benzyl-trimethylammonium hydroxide; acetic acid; diethylamine; In ethanol; dimethyl sulfoxide;
DOI:10.1021/jm00130a026