(S)-2-(2-(4-chlorophenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)acrylaldehyde

Base Information

Chemical Name:(S)-2-(2-(4-chlorophenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)acrylaldehyde
CAS No.:1391634-83-5
Molecular Formula:C₁₈H₁₆ClNO
Molecular Weight:297.784
Hs Code.:

Synonyms:(S)-2-(2-(4-chlorophenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)acrylaldehyde

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Chemical Property of (S)-2-(2-(4-chlorophenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)acrylaldehyde

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Technology Process of (S)-2-(2-(4-chlorophenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)acrylaldehyde

There total 2 articles about (S)-2-(2-(4-chlorophenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)acrylaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 78317-78-9
2-(4-chlorophenyl)-1,2,3,4-tetrahydroisoquinoline

: 107-02-8,25068-14-8
acrolein

: 1391634-83-5
(S)-2-(2-(4-chlorophenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)acrylaldehyde

Guidance literature:: With 5,6-bis(5-methoxythiophen-2-yl)pyrazine-2,3-dicarbonitrile; C₂₄H₁₀BF₁₈^(1-)*Na⁽¹⁺⁾; 4-(3-ethyl-4-oxa-1-azatricyclo[4,4,0,0(3,8)]dec-5-yl)quinolin-6-ol; In dichloromethane; at -20 ℃; for 48h; enantioselective reaction; Inert atmosphere; Irradiation;
DOI:10.1021/acscatal.6b00846

Reference yield: 51.0%

: 78317-78-9
2-(4-chlorophenyl)-1,2,3,4-tetrahydroisoquinoline

: 16979-06-9
2-oxo-2-vinylethanal

: 1391634-83-5
(S)-2-(2-(4-chlorophenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)acrylaldehyde

Guidance literature:: 2-(4-chlorophenyl)-1,2,3,4-tetrahydroisoquinoline; With oxygen; copper(II) bis(trifluoromethanesulfonate); quinine; sodium sulfate; In dichloromethane; at 20 ℃; under 760.051 Torr; Molecular sieve;

2-oxo-2-vinylethanal; In dichloromethane; at 20 ℃; for 72h; under 760.051 Torr; optical yield given as %ee; enantioselective reaction; Molecular sieve;
DOI:10.1021/ja303333k