(4S)-4-[N-benzyl-N-(3,5-hexadienoyl)amino]-5-phenyl-2-methyl-2-trans-pentenoic acid, ethyl ester

Base Information

Chemical Name:(4S)-4-[N-benzyl-N-(3,5-hexadienoyl)amino]-5-phenyl-2-methyl-2-trans-pentenoic acid, ethyl ester
CAS No.:244033-93-0
Molecular Formula:C₂₇H₃₁NO₃
Molecular Weight:417.548
Hs Code.:

Synonyms:(4S)-4-[N-benzyl-N-(3,5-hexadienoyl)amino]-5-phenyl-2-methyl-2-trans-pentenoic acid, ethyl ester

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Chemical Property of (4S)-4-[N-benzyl-N-(3,5-hexadienoyl)amino]-5-phenyl-2-methyl-2-trans-pentenoic acid, ethyl ester

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Technology Process of (4S)-4-[N-benzyl-N-(3,5-hexadienoyl)amino]-5-phenyl-2-methyl-2-trans-pentenoic acid, ethyl ester

There total 7 articles about (4S)-4-[N-benzyl-N-(3,5-hexadienoyl)amino]-5-phenyl-2-methyl-2-trans-pentenoic acid, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 73670-84-5
(E)-3,5-hexadienoyl chloride

: 244033-84-9
(4S)-4-N-benzylamino-5-phenyl-2-methyl-2-trans-pentenoic acid, ethyl ester

: 244033-93-0
(4S)-4-[N-benzyl-N-(3,5-hexadienoyl)amino]-5-phenyl-2-methyl-2-trans-pentenoic acid, ethyl ester

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 0.333333h;
DOI:10.1021/jo990459f

Reference yield:

: 3699-66-9
ethyl 2-diethoxyphosphorylpropionate

: 244033-93-0
(4S)-4-[N-benzyl-N-(3,5-hexadienoyl)amino]-5-phenyl-2-methyl-2-trans-pentenoic acid, ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 26 percent / potassium tert-butoxide / tetrahydrofuran / 2 h / 20 °C

2: CH₂Cl₂ / 0.33 h

3: NaCNBH₃; AcOH

4: Et₃N / tetrahydrofuran / 0.33 h / 20 °C

With potassium tert-butylate; sodium cyanoborohydride; acetic acid; triethylamine; In tetrahydrofuran; dichloromethane; 1: cyclocondensation / 2: deacylation / 3: Alkylation / 4: Acylation;
DOI:10.1021/jo990459f

Reference yield:

: 72155-45-4
Boc-L-phenylalaninal

: 244033-93-0
(4S)-4-[N-benzyl-N-(3,5-hexadienoyl)amino]-5-phenyl-2-methyl-2-trans-pentenoic acid, ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 26 percent / potassium tert-butoxide / tetrahydrofuran / 2 h / 20 °C

2: CH₂Cl₂ / 0.33 h

3: NaCNBH₃; AcOH

4: Et₃N / tetrahydrofuran / 0.33 h / 20 °C

With potassium tert-butylate; sodium cyanoborohydride; acetic acid; triethylamine; In tetrahydrofuran; dichloromethane; 1: cyclocondensation / 2: deacylation / 3: Alkylation / 4: Acylation;
DOI:10.1021/jo990459f