2-[1-(diphenylphosphinoyl)-2-(hydroxyimino)propylamino]-3-phenylpropionic acid methyl ester

Base Information

Chemical Name:2-[1-(diphenylphosphinoyl)-2-(hydroxyimino)propylamino]-3-phenylpropionic acid methyl ester
CAS No.:945483-87-4
Molecular Formula:C₂₅H₂₇N₂O₄P
Molecular Weight:450.474
Hs Code.:

Synonyms:2-[1-(diphenylphosphinoyl)-2-(hydroxyimino)propylamino]-3-phenylpropionic acid methyl ester

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Chemical Property of 2-[1-(diphenylphosphinoyl)-2-(hydroxyimino)propylamino]-3-phenylpropionic acid methyl ester

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Technology Process of 2-[1-(diphenylphosphinoyl)-2-(hydroxyimino)propylamino]-3-phenylpropionic acid methyl ester

There total 3 articles about 2-[1-(diphenylphosphinoyl)-2-(hydroxyimino)propylamino]-3-phenylpropionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 945483-93-2
C₁₅H₁₄NO₂P

: 7524-50-7
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

: 945483-87-4
2-[1-(diphenylphosphinoyl)-2-(hydroxyimino)propylamino]-3-phenylpropionic acid methyl ester

Guidance literature:: In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1021/jo0705521

Reference yield:

: 1-bromo-1-(diphenylphosphinoyl)propan-2-one oxime

: 945483-87-4
2-[1-(diphenylphosphinoyl)-2-(hydroxyimino)propylamino]-3-phenylpropionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / CH₂Cl₂ / cooling

2: 83 percent / CH₂Cl₂ / 0.5 h / 20 °C

With triethylamine; In dichloromethane; 2: Michael addition;
DOI:10.1021/jo0705521

Reference yield:

: 201932-61-8
(E)-β-(N-hydroxyimino)propyldiphenylphosphine oxide

: 945483-87-4
2-[1-(diphenylphosphinoyl)-2-(hydroxyimino)propylamino]-3-phenylpropionic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium methoxide / methanol / 1 h / Heating

1.2: 73 percent / bromine / methanol / 0 - 20 °C

2.1: triethylamine / CH₂Cl₂ / cooling

3.1: 83 percent / CH₂Cl₂ / 0.5 h / 20 °C

With sodium methylate; triethylamine; In methanol; dichloromethane; 3.1: Michael addition;
DOI:10.1021/jo0705521