3-{[1-(3-Nitro-phenyl)-meth-(E)-ylidene]-amino}-3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-one

Base Information

• Chemical Name: 3-{[1-(3-Nitro-phenyl)-meth-(E)-ylidene]-amino}-3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-one
• CAS No.: 99027-22-2
• Molecular Formula: C₁₇H₁₀N₄O₃S
• Molecular Weight: 350.357

Synonyms:3-{[1-(3-Nitro-phenyl)-meth-(E)-ylidene]-amino}-3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-one

Chemical Property of 3-{[1-(3-Nitro-phenyl)-meth-(E)-ylidene]-amino}-3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-one

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Technology Process of 3-{[1-(3-Nitro-phenyl)-meth-(E)-ylidene]-amino}-3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-one

There total 4 articles about 3-{[1-(3-Nitro-phenyl)-meth-(E)-ylidene]-amino}-3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3-nitro-benzaldehyde (99-61-6) + 3-amino<1>benzothieno<3,2-d>pyrimidin-4(3H)-one (99027-30-2) → 3-{[1-(3-Nitro-phenyl)-meth-(E)-ylidene]-amino}-3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-one (99027-22-2)

Guidance literature:

With boron trifluoride diethyl etherate; In ethanol; chloroform; for 2h; Heating;

DOI:10.1002/jhet.5570220236

Reference yield:

3-Amino-benzo[b]thiophene-2-carboxylic acid methyl ester (35212-85-2) → 3-{[1-(3-Nitro-phenyl)-meth-(E)-ylidene]-amino}-3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-one (99027-22-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 80 percent / 80percent hydrazine hydrate / ethanol / 2 h / Heating

2: 80 percent / 0.33 h / 180 °C

3: 92 percent / BF₃*Et₂O / ethanol; CHCl₃ / 2 h / Heating

With boron trifluoride diethyl etherate; hydrazine hydrate; In ethanol; chloroform;

DOI:10.1002/jhet.5570220236

Reference yield:

3-Aminobenzothiophene-2-carboxylic acid hydrazide (99027-29-9) → 3-{[1-(3-Nitro-phenyl)-meth-(E)-ylidene]-amino}-3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-one (99027-22-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / 0.33 h / 180 °C

2: 92 percent / BF₃*Et₂O / ethanol; CHCl₃ / 2 h / Heating

With boron trifluoride diethyl etherate; In ethanol; chloroform;

DOI:10.1002/jhet.5570220236

upstream raw materials:

3-nitro-benzaldehyde

3-amino<1>benzothieno<3,2-d>pyrimidin-4(3H)-one

3-Amino-benzo[b]thiophene-2-carboxylic acid methyl ester

3-Aminobenzothiophene-2-carboxylic acid hydrazide

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