N-Phenyl-N-<1-<2-(2-thienyl)ethyl>-4-piperidyl>propanamide Hydrochloride

Base Information

• Chemical Name: N-Phenyl-N-<1-<2-(2-thienyl)ethyl>-4-piperidyl>propanamide Hydrochloride
• CAS No.: 79278-88-9
• Molecular Formula: C₂₀H₂₆N₂OS*ClH
• Molecular Weight: 378.966

Synonyms:N-Phenyl-N-<1-<2-(2-thienyl)ethyl>-4-piperidyl>propanamide Hydrochloride

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Chemical Property of N-Phenyl-N-<1-<2-(2-thienyl)ethyl>-4-piperidyl>propanamide Hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-Phenyl-N-<1-<2-(2-thienyl)ethyl>-4-piperidyl>propanamide Hydrochloride

There total 11 articles about N-Phenyl-N-<1-<2-(2-thienyl)ethyl>-4-piperidyl>propanamide Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

thiofentanyl (1165-22-6) → N-Phenyl-N-<1-<2-(2-thienyl)ethyl>-4-piperidyl>propanamide Hydrochloride (79278-88-9)

Guidance literature:

With hydrogenchloride; In diethyl ether; water; at 20 ℃; for 2h;

DOI:10.1371/journal.pone.0108250

Reference yield:

1-phenylmethyl-4-piperidone (3612-20-2) → N-Phenyl-N-<1-<2-(2-thienyl)ethyl>-4-piperidyl>propanamide Hydrochloride (79278-88-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 1) p-toluenesulfonic acid monohydrate, 2) NaBH₄ / 1) toluene, 22 h, reflux, 2) ethanol, rt, 3 h

2: toluene / 3 h / Heating

3: 95 percent / H₂, conc. HCl / 10 percent Pd/C / ethanol / 50 °C / 2068.6 Torr

4: 1) sodium carbonate, 2) HCl / 1) toluene, reflux, 3,5 h, 2) diethyl ether

With hydrogenchloride; sodium tetrahydroborate; hydrogen; sodium carbonate; toluene-4-sulfonic acid; palladium on activated charcoal; In ethanol; toluene;

DOI:10.1002/jhet.5570260329

Reference yield:

N-(1-benzyl-4-piperidinyl)-N-phenylpropionamide (1474-02-8) → N-Phenyl-N-<1-<2-(2-thienyl)ethyl>-4-piperidyl>propanamide Hydrochloride (79278-88-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / H₂, conc. HCl / 10 percent Pd/C / ethanol / 50 °C / 2068.6 Torr

2: 1) sodium carbonate, 2) HCl / 1) toluene, reflux, 3,5 h, 2) diethyl ether

With hydrogenchloride; hydrogen; sodium carbonate; palladium on activated charcoal; In ethanol;

DOI:10.1002/jhet.5570260329

upstream raw materials:

2-(2-thienyl)ethyl tosylate

Norfentanyl

2-thiophenethanol

1-phenylmethyl-4-piperidone