Technology Process of 3-[(Z)-2-(2-methylcyclopropyl)vinyl]-5-[methyl(methylsulfonyl)amino]benzoic acid
There total 7 articles about 3-[(Z)-2-(2-methylcyclopropyl)vinyl]-5-[methyl(methylsulfonyl)amino]benzoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C16H21NO4S;
With
sodium hydroxide; water;
In
tetrahydrofuran; methanol;
at 20 ℃;
for 2h;
With
hydrogenchloride;
In
water;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: N-iodo-succinimide; trifluorormethanesulfonic acid / 48 h / 0 °C
2.1: ethanol; tin(ll) chloride / tetrahydrofuran / 0.5 h / Heating / reflux
2.2: 0 °C / pH 8 - 9
3.1: pyridine / dichloromethane / 0 - 20 °C
4.1: sodium hydride / DMF (N,N-dimethyl-formamide) / 0.5 h / 0 °C
4.2: 12 h / 0 - 20 °C
5.1: indium(III) chloride; triethyl borane; diisobutylaluminium hydride / tetrahydrofuran; hexanes / 3 h / -78 - 20 °C
5.2: 2 h / 60 °C
6.1: methanol; sodium hydroxide; water / tetrahydrofuran / 2 h / 20 °C
With
pyridine; methanol; indium(III) chloride; sodium hydroxide; N-iodo-succinimide; ethanol; triethyl borane; trifluorormethanesulfonic acid; water; sodium hydride; diisobutylaluminium hydride; tin(ll) chloride;
In
tetrahydrofuran; hexanes; DMF (N,N-dimethyl-formamide); dichloromethane;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: pyridinium chlorochromate / dichloromethane / 3 h / 20 °C
2.1: triphenylphosphine / dichloromethane / 1.67 h / 0 - 20 °C
3.1: n-butyllithium / cyclohexane / 3 h / -78 - 20 °C
4.1: indium(III) chloride; triethyl borane; diisobutylaluminium hydride / tetrahydrofuran; hexanes / 3 h / -78 - 20 °C
4.2: 2 h / 60 °C
5.1: methanol; sodium hydroxide; water / tetrahydrofuran / 2 h / 20 °C
With
methanol; indium(III) chloride; sodium hydroxide; n-butyllithium; triethyl borane; water; diisobutylaluminium hydride; triphenylphosphine; pyridinium chlorochromate;
In
tetrahydrofuran; hexanes; dichloromethane; cyclohexane;
2.1: Corey-Fuchs Reaction;
