3-O-(4'-benzhydryloxy-3',3'-dimethylsuccinyl)-28-O-(3'',3''-dimethylglutaryl)dihydrobetulin

Base Information

• Chemical Name: 3-O-(4'-benzhydryloxy-3',3'-dimethylsuccinyl)-28-O-(3'',3''-dimethylglutaryl)dihydrobetulin
• CAS No.: 1252258-53-9
• Molecular Formula: C₅₆H₈₀O₈
• Molecular Weight: 881.246
• Mol file: 1252258-53-9.mol

Synonyms:3-O-(4'-benzhydryloxy-3',3'-dimethylsuccinyl)-28-O-(3'',3''-dimethylglutaryl)dihydrobetulin

Chemical Property of 3-O-(4'-benzhydryloxy-3',3'-dimethylsuccinyl)-28-O-(3'',3''-dimethylglutaryl)dihydrobetulin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-O-(4'-benzhydryloxy-3',3'-dimethylsuccinyl)-28-O-(3'',3''-dimethylglutaryl)dihydrobetulin

There total 1 articles about 3-O-(4'-benzhydryloxy-3',3'-dimethylsuccinyl)-28-O-(3'',3''-dimethylglutaryl)dihydrobetulin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3,3-dimethylglutaric anhydride (4160-82-1) + 3-O-(3',3'-dimethylsuccinyl)dihydrobetulin benzhydryl ester (1252258-42-6) → 3-O-(4'-benzhydryloxy-3',3'-dimethylsuccinyl)-28-O-(3'',3''-dimethylglutaryl)dihydrobetulin (1252258-53-9)

Guidance literature:

3,3-dimethylglutaric anhydride; 3-O-(3',3'-dimethylsuccinyl)dihydrobetulin benzhydryl ester; With pyridine; dmap; Reflux;

With water; Cooling with ice;

DOI:10.1016/j.bmc.2010.06.092

Reference yield: 66.1%

3-O-(4'-benzhydryloxy-3',3'-dimethylsuccinyl)-28-O-(3'',3''-dimethylglutaryl)dihydrobetulin (1252258-53-9) + 3'-azido-2',3'-deoxythymidine (30516-87-1,399024-19-2) → 3'-azido-3'-deoxythymidin-5'-yl 3-O-(4'-benzhydryloxy-3',3'-dimethylsuccinyl)-lup-28-yl 3,3-dimethylglutarate (1252258-67-5)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃;

DOI:10.1016/j.bmc.2010.06.092

upstream raw materials:

3,3-dimethylglutaric anhydride

3-O-(3',3'-dimethylsuccinyl)dihydrobetulin benzhydryl ester

Downstream raw materials:

3'-azido-3'-deoxythymidin-5'-yl 3-O-(4'-benzhydryloxy-3',3'-dimethylsuccinyl)-lup-28-yl 3,3-dimethylglutarate