8--phenyloctyl--N--Boc--(2S)--2--amino--3--(1--(8--phenyloctyl)--1H--indol--3-yl)propanoate

Base Information

Chemical Name:8--phenyloctyl--N--Boc--(2S)--2--amino--3--(1--(8--phenyloctyl)--1H--indol--3-yl)propanoate
CAS No.:1415221-93-0
Molecular Formula:C₄₄H₆₀N₂O₄
Molecular Weight:680.971
Hs Code.:

Synonyms:8--phenyloctyl--N--Boc--(2S)--2--amino--3--(1--(8--phenyloctyl)--1H--indol--3-yl)propanoate

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Chemical Property of 8--phenyloctyl--N--Boc--(2S)--2--amino--3--(1--(8--phenyloctyl)--1H--indol--3-yl)propanoate

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Technology Process of 8--phenyloctyl--N--Boc--(2S)--2--amino--3--(1--(8--phenyloctyl)--1H--indol--3-yl)propanoate

There total 2 articles about 8--phenyloctyl--N--Boc--(2S)--2--amino--3--(1--(8--phenyloctyl)--1H--indol--3-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 128502-58-9
8-phenyloctyl iodide

: 13139-14-5
Boc-Trp-OH

: 1415221-93-0
8--phenyloctyl--N--Boc--(2S)--2--amino--3--(1--(8--phenyloctyl)--1H--indol--3-yl)propanoate

Guidance literature:: With sodium hydroxide; In dimethyl sulfoxide; at 40 ℃; for 6h;
DOI:10.1016/j.bmcl.2012.10.093

Reference yield:

: 10472-97-6
8-phenyloctan-1-ol

: 1415221-93-0
8--phenyloctyl--N--Boc--(2S)--2--amino--3--(1--(8--phenyloctyl)--1H--indol--3-yl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: triphenylphosphine; 1H-imidazole; iodine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

2: sodium hydroxide / dimethyl sulfoxide / 6 h / 40 °C

With 1H-imidazole; iodine; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1016/j.bmcl.2012.10.093