(S)-(tert-Butyl-diphenyl-silanyloxy)-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-acetaldehyde

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Chemical Name:(S)-(tert-Butyl-diphenyl-silanyloxy)-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-acetaldehyde
CAS No.:303158-51-2
Molecular Formula:C₂₃H₃₀O₄Si
Molecular Weight:398.574
Hs Code.:

Synonyms:(S)-(tert-Butyl-diphenyl-silanyloxy)-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-acetaldehyde

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Chemical Property of (S)-(tert-Butyl-diphenyl-silanyloxy)-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-acetaldehyde

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Technology Process of (S)-(tert-Butyl-diphenyl-silanyloxy)-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-acetaldehyde

There total 5 articles about (S)-(tert-Butyl-diphenyl-silanyloxy)-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 209479-86-7
(2R,3R)-3-O-tert-butyldiphenylsilyl-1,2-O-isopropylidene-4-pentene-1,2,3-triol

: 303158-51-2
(S)-(tert-Butyl-diphenyl-silanyloxy)-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-acetaldehyde

Guidance literature:: (2R,3R)-3-O-tert-butyldiphenylsilyl-1,2-O-isopropylidene-4-pentene-1,2,3-triol; In dichloromethane;

With dimethylsulfide; Further stages.;
DOI:10.1021/ol0063656

Reference yield:

: 18524-18-0
(R)-1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)prop-2-en-1-ol

: 303158-51-2
(S)-(tert-Butyl-diphenyl-silanyloxy)-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-acetaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: 98 percent / imidazole / dimethylformamide

2.1: CH₂Cl₂

2.2: 98 percent / Me₂S

With 1H-imidazole; In dichloromethane; N,N-dimethyl-formamide; 1.1: silylation / 2.1: ozonation / 2.2: Reduction;
DOI:10.1021/ol0063656

Reference yield:

: 102357-25-5
(1S,4'R)-1-(2,2-dimethyl-1,3-dioxolane-4-yl)-2-trimethylsilylprop-2-en-1-ol

: 303158-51-2
(S)-(tert-Butyl-diphenyl-silanyloxy)-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-acetaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1.1: 95 percent / NaH; HMPA

2.1: 98 percent / imidazole / dimethylformamide

3.1: CH₂Cl₂

3.2: 98 percent / Me₂S

With 1H-imidazole; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydride; In dichloromethane; N,N-dimethyl-formamide; 1.1: protodesilylation / 2.1: silylation / 3.1: ozonation / 3.2: Reduction;
DOI:10.1021/ol0063656