(5S)-[N-3-(3'-fluoro-4'-(1(H)-pyrrolyl)phenyl)-2-oxo-5-oxazolidinyl]methylamine

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Chemical Name:(5S)-[N-3-(3'-fluoro-4'-(1(H)-pyrrolyl)phenyl)-2-oxo-5-oxazolidinyl]methylamine
CAS No.:343880-90-0
Molecular Formula:C₁₄H₁₄FN₃O₂
Molecular Weight:275.282
Hs Code.:

Synonyms:(5S)-[N-3-(3'-fluoro-4'-(1(H)-pyrrolyl)phenyl)-2-oxo-5-oxazolidinyl]methylamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (5S)-[N-3-(3'-fluoro-4'-(1(H)-pyrrolyl)phenyl)-2-oxo-5-oxazolidinyl]methylamine

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Technology Process of (5S)-[N-3-(3'-fluoro-4'-(1(H)-pyrrolyl)phenyl)-2-oxo-5-oxazolidinyl]methylamine

There total 10 articles about (5S)-[N-3-(3'-fluoro-4'-(1(H)-pyrrolyl)phenyl)-2-oxo-5-oxazolidinyl]methylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 226220-33-3
(R)-5-Azidomethyl-3-(3-fluoro-4-pyrrol-1-yl-phenyl)-oxazolidin-2-one

: 343880-90-0
(5S)-[N-3-(3'-fluoro-4'-(1(H)-pyrrolyl)phenyl)-2-oxo-5-oxazolidinyl]methylamine

Guidance literature:: With water; triphenylphosphine; In tetrahydrofuran; at 40 ℃; for 17h;
DOI:10.1248/cpb.49.361

Reference yield: 65.7%

: 343880-90-0
(5S)-[N-3-(3'-fluoro-4'-(1(H)-pyrrolyl)phenyl)-2-oxo-5-oxazolidinyl]methylamine

Guidance literature:: With methylamine; In ethanol; water; for 7.5h; Reflux;

Reference yield:

: 369-34-6
3,4-difluoronitrobenzene

: 343880-90-0
(5S)-[N-3-(3'-fluoro-4'-(1(H)-pyrrolyl)phenyl)-2-oxo-5-oxazolidinyl]methylamine

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / tetrahydrofuran / 0.25 h / 50 °C

1.2: 66 percent / tetrahydrofuran / 18 h / Heating

2.1: H₂ / 5percent Pt/S/C / tetrahydrofuran / 18 h

3.1: NaHCO₃ / tetrahydrofuran / 48 h / 20 °C

4.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 0.5 h / -78 °C

4.2: 59 percent / tetrahydrofuran / 24 h / 20 °C

5.1: NEt₃ / CH₂Cl₂ / 0.5 h / 0 °C

6.1: sodium azide / dimethylformamide / 18 h / 60 °C

7.1: H₂ / Pd/C / methanol; tetrahydrofuran / 24 h / 760.05 Torr

With sodium azide; hydrogen; sodium hydride; sodium hydrogencarbonate; triethylamine; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 1.1: Metallation / 1.2: Substitution / 2.1: Reduction / 3.1: Acylation / 4.1: Metallation / 4.2: Ring cleavage / 5.1: mesylation / 6.1: Substitution / 7.1: Reduction;
DOI:10.1021/jm990373e