(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-1-methyl-pyrrolidine-2-carboxylic acid [(S)-2-hydroxy-1-(1H-imidazol-4-ylmethyl)-ethyl]-amide trifluoroacetate salt

Base Information

Chemical Name:(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-1-methyl-pyrrolidine-2-carboxylic acid [(S)-2-hydroxy-1-(1H-imidazol-4-ylmethyl)-ethyl]-amide trifluoroacetate salt
CAS No.:1354692-93-5
Molecular Formula:C₂HF₃O₂*C₃₀H₃₃Cl₂F₂N₅O₂
Molecular Weight:718.551
Hs Code.:

(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-1-methyl-pyrrolidine-2-carboxylic acid [(S)-2-hydroxy-1-(1H-imidazol-4-ylmethyl)-ethyl]-amide trifluoroacetate salt

Synonyms:(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-1-methyl-pyrrolidine-2-carboxylic acid [(S)-2-hydroxy-1-(1H-imidazol-4-ylmethyl)-ethyl]-amide trifluoroacetate salt

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Chemical Property of (2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-1-methyl-pyrrolidine-2-carboxylic acid [(S)-2-hydroxy-1-(1H-imidazol-4-ylmethyl)-ethyl]-amide trifluoroacetate salt

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Technology Process of (2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-1-methyl-pyrrolidine-2-carboxylic acid [(S)-2-hydroxy-1-(1H-imidazol-4-ylmethyl)-ethyl]-amide trifluoroacetate salt

There total 3 articles about (2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-1-methyl-pyrrolidine-2-carboxylic acid [(S)-2-hydroxy-1-(1H-imidazol-4-ylmethyl)-ethyl]-amide trifluoroacetate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.1%

: 1354693-55-2
(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-1-methyl-pyrrolidine-2-carboxylic acid

: 1596-64-1
2-(S)-amino-3-(1H-imidazol-4⁽⁵⁾-yl)propanol dihydrochloride

: 1354692-93-5
(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-1-methyl-pyrrolidine-2-carboxylic acid [(S)-2-hydroxy-1-(1H-imidazol-4-ylmethyl)-ethyl]-amide trifluoroacetate salt

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 20 ℃; for 14h;

Reference yield:

: 1354693-60-9
rac-(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-pyrrolidine-2-carboxylic acid methyl ester

: 1354692-93-5
(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-1-methyl-pyrrolidine-2-carboxylic acid [(S)-2-hydroxy-1-(1H-imidazol-4-ylmethyl)-ethyl]-amide trifluoroacetate salt

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tris(acetoxy)borohydride; acetic acid / 0 - 20 °C

2: lithium hydroxide / tetrahydrofuran; methanol / 5 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 14 h / 20 °C

With sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 1354693-56-3
(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-1-methylpyrrolidine-2-carboxylic acid methyl ester

: 1354692-93-5
(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-1-methyl-pyrrolidine-2-carboxylic acid [(S)-2-hydroxy-1-(1H-imidazol-4-ylmethyl)-ethyl]-amide trifluoroacetate salt

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide / tetrahydrofuran; methanol / 5 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 14 h / 20 °C

With N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane;