tert-butyl cyclopentyl(4-{[6-oxo-3-(trifluoromethyl)pyridazin-1(6H)-yl]methyl}phenyl)acetate

Base Information

Chemical Name:tert-butyl cyclopentyl(4-{[6-oxo-3-(trifluoromethyl)pyridazin-1(6H)-yl]methyl}phenyl)acetate
CAS No.:1192040-30-4
Molecular Formula:C₂₃H₂₇F₃N₂O₃
Molecular Weight:436.474
Hs Code.:

Synonyms:tert-butyl cyclopentyl(4-{[6-oxo-3-(trifluoromethyl)pyridazin-1(6H)-yl]methyl}phenyl)acetate

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Chemical Property of tert-butyl cyclopentyl(4-{[6-oxo-3-(trifluoromethyl)pyridazin-1(6H)-yl]methyl}phenyl)acetate

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Technology Process of tert-butyl cyclopentyl(4-{[6-oxo-3-(trifluoromethyl)pyridazin-1(6H)-yl]methyl}phenyl)acetate

There total 4 articles about tert-butyl cyclopentyl(4-{[6-oxo-3-(trifluoromethyl)pyridazin-1(6H)-yl]methyl}phenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 174607-36-4
6-(trifluoromethyl)pyridazin-3(2H)-one

: 157312-16-8
tert-butyl [4-(bromomethyl)phenyl](cyclopentyl)acetate

: 1192040-30-4
tert-butyl cyclopentyl(4-{[6-oxo-3-(trifluoromethyl)pyridazin-1(6H)-yl]methyl}phenyl)acetate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1021/acs.jmedchem.0c02154

Reference yield:

: 157312-15-7
tert-butyl cyclopentyl(4-methylphenyl)acetate

: 1192040-30-4
tert-butyl cyclopentyl(4-{[6-oxo-3-(trifluoromethyl)pyridazin-1(6H)-yl]methyl}phenyl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / chloroform / 2 h / Reflux

2: caesium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); caesium carbonate; In chloroform; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.0c02154

Reference yield:

: 33155-60-1
t-butyl p-tolylacetate

: 1192040-30-4
tert-butyl cyclopentyl(4-{[6-oxo-3-(trifluoromethyl)pyridazin-1(6H)-yl]methyl}phenyl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

1.2: 2 h / 0 °C / Inert atmosphere

2.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / chloroform / 2 h / Reflux

3.1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium tert-butylate; caesium carbonate; In chloroform; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.0c02154