(2S)-2-[(tert-butoxycarbonyl)amino]-3-{4-[(diethoxyphosphoryl)(difluoro)methyl]phenyl}propyl acetate

Base Information

Chemical Name:(2S)-2-[(tert-butoxycarbonyl)amino]-3-{4-[(diethoxyphosphoryl)(difluoro)methyl]phenyl}propyl acetate
CAS No.:213127-95-8
Molecular Formula:C₂₁H₃₂F₂NO₇P
Molecular Weight:479.458
Hs Code.:

Synonyms:(2S)-2-[(tert-butoxycarbonyl)amino]-3-{4-[(diethoxyphosphoryl)(difluoro)methyl]phenyl}propyl acetate

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Chemical Property of (2S)-2-[(tert-butoxycarbonyl)amino]-3-{4-[(diethoxyphosphoryl)(difluoro)methyl]phenyl}propyl acetate

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Technology Process of (2S)-2-[(tert-butoxycarbonyl)amino]-3-{4-[(diethoxyphosphoryl)(difluoro)methyl]phenyl}propyl acetate

There total 9 articles about (2S)-2-[(tert-butoxycarbonyl)amino]-3-{4-[(diethoxyphosphoryl)(difluoro)methyl]phenyl}propyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 213127-93-6
(2S)-2-{[(benzyloxy)carbonyl]amino}-3-{4-[(diethoxyphosphoryl)(difluoro)methyl]phenyl}propyl acetate

: 213127-95-8
(2S)-2-[(tert-butoxycarbonyl)amino]-3-{4-[(diethoxyphosphoryl)(difluoro)methyl]phenyl}propyl acetate

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; at 20 ℃; for 12h; under 760 Torr;
DOI:10.1016/S0040-4020(98)00586-9

Reference yield:

: 624-31-7
4-tolyl iodide

: 213127-95-8
(2S)-2-[(tert-butoxycarbonyl)amino]-3-{4-[(diethoxyphosphoryl)(difluoro)methyl]phenyl}propyl acetate

Guidance literature:: Multi-step reaction with 8 steps

1: 80 percent / Zn; CuBr / N,N-dimethyl-acetamide / ultrasound

2: N-bromosuccinimide; AIBN / CCl₄ / 3 h / 90 °C

3: 71 percent / NaH / tetrahydrofuran / 0.5 h / 20 °C

4: 64 percent / NaBH₄ / methanol / 2 h / 20 °C

5: 82 percent / lipase PS / tetrahydrofuran / 2 h / 25 °C / Enzymatic reaction

6: Jones reagent / acetone / 4 h / 20 °C

7: 52 percent / diphenylphosphoryl azide; triethylamine / benzene / 24 h / Heating

8: 83 percent / H₂ / Pd-C / ethyl acetate / 12 h / 20 °C / 760 Torr

With sodium tetrahydroborate; N-Bromosuccinimide; jones reagent; Lipase PS; 2,2'-azobis(isobutyronitrile); diphenylphosphoranyl azide; hydrogen; sodium hydride; triethylamine; copper(I) bromide; zinc; palladium on activated charcoal; In tetrahydrofuran; methanol; tetrachloromethane; N,N-dimethyl acetamide; ethyl acetate; acetone; benzene; 1: Substitution / 2: Bromination / 3: Substitution / 4: Reduction / 5: Acetylation / 6: Oxidation / 7: Rearrangement / 8: Substitution;
DOI:10.1016/S0040-4020(98)00586-9

Reference yield:

: 65094-22-6
diethyl (bromodifluoromethyl)phosphonate

: 213127-95-8
(2S)-2-[(tert-butoxycarbonyl)amino]-3-{4-[(diethoxyphosphoryl)(difluoro)methyl]phenyl}propyl acetate

Guidance literature:: Multi-step reaction with 8 steps

1: 80 percent / Zn; CuBr / N,N-dimethyl-acetamide / ultrasound

2: N-bromosuccinimide; AIBN / CCl₄ / 3 h / 90 °C

3: 71 percent / NaH / tetrahydrofuran / 0.5 h / 20 °C

4: 64 percent / NaBH₄ / methanol / 2 h / 20 °C

5: 82 percent / lipase PS / tetrahydrofuran / 2 h / 25 °C / Enzymatic reaction

6: Jones reagent / acetone / 4 h / 20 °C

7: 52 percent / diphenylphosphoryl azide; triethylamine / benzene / 24 h / Heating

8: 83 percent / H₂ / Pd-C / ethyl acetate / 12 h / 20 °C / 760 Torr

With sodium tetrahydroborate; N-Bromosuccinimide; jones reagent; Lipase PS; 2,2'-azobis(isobutyronitrile); diphenylphosphoranyl azide; hydrogen; sodium hydride; triethylamine; copper(I) bromide; zinc; palladium on activated charcoal; In tetrahydrofuran; methanol; tetrachloromethane; N,N-dimethyl acetamide; ethyl acetate; acetone; benzene; 1: Substitution / 2: Bromination / 3: Substitution / 4: Reduction / 5: Acetylation / 6: Oxidation / 7: Rearrangement / 8: Substitution;
DOI:10.1016/S0040-4020(98)00586-9