[3-(2-aminopyrimidin-4-yl)-2-(3-bromo-4-fluorophenyl)imidazo[1,2-a]pyridin-7-yl]methanol

Base Information

• Chemical Name: [3-(2-aminopyrimidin-4-yl)-2-(3-bromo-4-fluorophenyl)imidazo[1,2-a]pyridin-7-yl]methanol
• CAS No.: 1001922-58-2
• Molecular Formula: C₁₈H₁₃BrFN₅O
• Molecular Weight: 414.237

Synonyms:[3-(2-aminopyrimidin-4-yl)-2-(3-bromo-4-fluorophenyl)imidazo[1,2-a]pyridin-7-yl]methanol

Chemical Property of [3-(2-aminopyrimidin-4-yl)-2-(3-bromo-4-fluorophenyl)imidazo[1,2-a]pyridin-7-yl]methanol

Chemical Property:

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Technology Process of [3-(2-aminopyrimidin-4-yl)-2-(3-bromo-4-fluorophenyl)imidazo[1,2-a]pyridin-7-yl]methanol

There total 1 articles about [3-(2-aminopyrimidin-4-yl)-2-(3-bromo-4-fluorophenyl)imidazo[1,2-a]pyridin-7-yl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

[2-(3-bromo-4-fluorophenyl)-3-(2-methylsulfonylpyrimidin-4-yl)imidazo[1,2-a]pyridin-7-yl]methanol (1001922-52-6) → [3-(2-aminopyrimidin-4-yl)-2-(3-bromo-4-fluorophenyl)imidazo[1,2-a]pyridin-7-yl]methanol (1001922-58-2)

Guidance literature:

With ammonia; In tetrahydrofuran; at -78 - 20 ℃; for 12h; under 2068.65 - 2585.81 Torr;

DOI:10.1016/j.ejmech.2007.02.006

Reference yield: 58.0%

[3-(2-aminopyrimidin-4-yl)-2-(3-bromo-4-fluorophenyl)imidazo[1,2-a]pyridin-7-yl]methanol (1001922-58-2) → 3-(2-aminopyrimidin-4-yl)-2-(3-bromo-4-fluorophenyl)imidazo[1,2-a]pyridine-7-carbaldehyde (1001922-59-3)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1016/j.ejmech.2007.02.006

upstream raw materials:

[2-(3-bromo-4-fluorophenyl)-3-(2-methylsulfonylpyrimidin-4-yl)imidazo[1,2-a]pyridin-7-yl]methanol

Downstream raw materials:

3-(2-aminopyrimidin-4-yl)-2-(3-bromo-4-fluorophenyl)imidazo[1,2-a]pyridine-7-carbaldehyde

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