3-methyl-2-buten-1-yl 2-(2-(2,2-dimethyl-4-oxo-4H-1,3-dioxin-6-yl)acetyl)-3-oxo-5-phenylpentanoate

Base Information

Chemical Name:3-methyl-2-buten-1-yl 2-(2-(2,2-dimethyl-4-oxo-4H-1,3-dioxin-6-yl)acetyl)-3-oxo-5-phenylpentanoate
CAS No.:1353896-13-5
Molecular Formula:C₂₄H₂₈O₇
Molecular Weight:428.482
Hs Code.:

Synonyms:3-methyl-2-buten-1-yl 2-(2-(2,2-dimethyl-4-oxo-4H-1,3-dioxin-6-yl)acetyl)-3-oxo-5-phenylpentanoate

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Chemical Property of 3-methyl-2-buten-1-yl 2-(2-(2,2-dimethyl-4-oxo-4H-1,3-dioxin-6-yl)acetyl)-3-oxo-5-phenylpentanoate

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Technology Process of 3-methyl-2-buten-1-yl 2-(2-(2,2-dimethyl-4-oxo-4H-1,3-dioxin-6-yl)acetyl)-3-oxo-5-phenylpentanoate

There total 4 articles about 3-methyl-2-buten-1-yl 2-(2-(2,2-dimethyl-4-oxo-4H-1,3-dioxin-6-yl)acetyl)-3-oxo-5-phenylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1334485-04-9
3-methylbut-2-enyl 4-(2,2-dimethyl-4-oxo-4H-1,3-dioxin-6-yl)-3-oxobutanoate

: 645-45-4
hydrocinnamic acid chloride

: 1353896-13-5
3-methyl-2-buten-1-yl 2-(2-(2,2-dimethyl-4-oxo-4H-1,3-dioxin-6-yl)acetyl)-3-oxo-5-phenylpentanoate

Guidance literature:: 3-methylbut-2-enyl 4-(2,2-dimethyl-4-oxo-4H-1,3-dioxin-6-yl)-3-oxobutanoate; With pyridine; magnesium chloride; In dichloromethane; at 0 ℃; for 0.5h; Inert atmosphere;

hydrocinnamic acid chloride; In dichloromethane; at 0 ℃; for 1h; regioselective reaction; Inert atmosphere;
DOI:10.1016/j.tetlet.2011.11.019

Reference yield:

: 5394-63-8
2,2,6-trimethyl-4H-1,3-dioxin-4-one

: 1353896-13-5
3-methyl-2-buten-1-yl 2-(2-(2,2-dimethyl-4-oxo-4H-1,3-dioxin-6-yl)acetyl)-3-oxo-5-phenylpentanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium; 1,1,1,3,3,3-hexamethyl-disilazane / cyclohexane; tetrahydrofuran / 1 h / -78 °C

1.2: 18 h / -78 - 25 °C

2.1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 18 h / 25 °C

3.1: toluene / 4 h / 55 °C

4.1: magnesium chloride; pyridine / dichloromethane / 0.17 h / 0 °C

4.2: 1 h / 0 °C

With pyridine; dmap; n-butyllithium; dicyclohexyl-carbodiimide; 1,1,1,3,3,3-hexamethyl-disilazane; magnesium chloride; In tetrahydrofuran; dichloromethane; cyclohexane; toluene;
DOI:10.1002/ejoc.202001487

Reference yield:

: 2-(2,2-dimethyl-4-oxo-4H-1,3-dioxin-6-yl)acetic acid

: 1353896-13-5
3-methyl-2-buten-1-yl 2-(2-(2,2-dimethyl-4-oxo-4H-1,3-dioxin-6-yl)acetyl)-3-oxo-5-phenylpentanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 18 h / 25 °C

2.1: toluene / 4 h / 55 °C

3.1: magnesium chloride; pyridine / dichloromethane / 0.17 h / 0 °C

3.2: 1 h / 0 °C

With pyridine; dmap; dicyclohexyl-carbodiimide; magnesium chloride; In dichloromethane; toluene;
DOI:10.1002/ejoc.202001487