4-methoxy-N-[3-(6-methoxy-2-methylquinolin-4-yl)-2-oxo-oxazolidin-5-ylmethyl]-2-methylbenzamide

Base Information

Chemical Name:4-methoxy-N-[3-(6-methoxy-2-methylquinolin-4-yl)-2-oxo-oxazolidin-5-ylmethyl]-2-methylbenzamide
CAS No.:1341167-30-3
Molecular Formula:C₂₄H₂₅N₃O₅
Molecular Weight:435.48
Hs Code.:

Synonyms:4-methoxy-N-[3-(6-methoxy-2-methylquinolin-4-yl)-2-oxo-oxazolidin-5-ylmethyl]-2-methylbenzamide

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Chemical Property of 4-methoxy-N-[3-(6-methoxy-2-methylquinolin-4-yl)-2-oxo-oxazolidin-5-ylmethyl]-2-methylbenzamide

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Technology Process of 4-methoxy-N-[3-(6-methoxy-2-methylquinolin-4-yl)-2-oxo-oxazolidin-5-ylmethyl]-2-methylbenzamide

There total 7 articles about 4-methoxy-N-[3-(6-methoxy-2-methylquinolin-4-yl)-2-oxo-oxazolidin-5-ylmethyl]-2-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 31310-08-4
2-methyl-4-methoxybenzoyl chloride

: 1341166-99-1
5-aminomethyl-3-(6-methoxy-2-methyl-quinolin-4-yl)-oxazolidin-2-one

: 1341167-30-3
4-methoxy-N-[3-(6-methoxy-2-methylquinolin-4-yl)-2-oxo-oxazolidin-5-ylmethyl]-2-methylbenzamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 0.5h;
DOI:10.1016/j.ejmech.2011.07.049

Reference yield:

: 1341166-96-8
5-azidomethyl-3-(6-methoxy-2-methyl-quinolin-4-yl)-oxazolidin-2-one

: 1341167-30-3
4-methoxy-N-[3-(6-methoxy-2-methylquinolin-4-yl)-2-oxo-oxazolidin-5-ylmethyl]-2-methylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 2206.72 Torr

2: triethylamine / dichloromethane / 0.5 h / 0 °C

With palladium 10% on activated carbon; hydrogen; triethylamine; In methanol; dichloromethane;
DOI:10.1016/j.ejmech.2011.07.049

Reference yield:

: 1341166-91-3
(6-methoxy-2-methylquinolin-4-yl)-carbamic acid benzyl ester

: 1341167-30-3
4-methoxy-N-[3-(6-methoxy-2-methylquinolin-4-yl)-2-oxo-oxazolidin-5-ylmethyl]-2-methylbenzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 0 - 15 °C

1.2: 0 - 25 °C

2.1: iodine / acetonitrile / 20 h / 26 - 30 °C

3.1: sodium azide / N,N-dimethyl-formamide / 2 h / 25 °C

4.1: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 2206.72 Torr

5.1: triethylamine / dichloromethane / 0.5 h / 0 °C

With sodium azide; palladium 10% on activated carbon; hydrogen; iodine; sodium hydride; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.ejmech.2011.07.049