1-(tetrahydropyranyloxy)-3-hydroxy-2,2-diphenylpropane

Base Information

• Chemical Name: 1-(tetrahydropyranyloxy)-3-hydroxy-2,2-diphenylpropane
• CAS No.: 118318-20-0
• Molecular Formula: C₂₀H₂₄O₃
• Molecular Weight: 312.409
• Mol file: 118318-20-0.mol

Synonyms:1-(tetrahydropyranyloxy)-3-hydroxy-2,2-diphenylpropane

Chemical Property of 1-(tetrahydropyranyloxy)-3-hydroxy-2,2-diphenylpropane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(tetrahydropyranyloxy)-3-hydroxy-2,2-diphenylpropane

There total 1 articles about 1-(tetrahydropyranyloxy)-3-hydroxy-2,2-diphenylpropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.4%

3,4-dihydro-2H-pyran (110-87-2) + 2,2-diphenyl-1,3-propanediol (5464-86-8) → 1-(tetrahydropyranyloxy)-3-hydroxy-2,2-diphenylpropane (118318-20-0) + 1,3-bis(tetrahydropyranyloxy)-2,2-diphenylpropane

Guidance literature:

With pyridinium p-toluenesulfonate; In dichloromethane; for 18h; Ambient temperature;

DOI:10.1021/ja00185a033

Reference yield: 81.5%

1-(tetrahydropyranyloxy)-3-hydroxy-2,2-diphenylpropane (118318-20-0) → 3-(tetrahydropyranyloxy)-2,2-diphenylpropan-1-al (118318-40-4)

Guidance literature:

With sodium acetate; pyridinium chlorochromate; In dichloromethane; for 14h;

DOI:10.1021/ja00185a033

Reference yield:

1-(tetrahydropyranyloxy)-3-hydroxy-2,2-diphenylpropane (118318-20-0) → 1-(tetrahydropyranyloxy)-4-methyl-2,2-diphenyl-3-pentene (118318-21-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 81.5 percent / pyridinium chlorochromate, sodium acetate / CH₂Cl₂ / 14 h

2: 1.) n-butyllithium / 1.) toluene, hexane, 45 min; 2.) 3 h

With n-butyllithium; sodium acetate; pyridinium chlorochromate; In dichloromethane;

DOI:10.1021/ja00185a033

upstream raw materials:

3,4-dihydro-2H-pyran

2,2-diphenyl-1,3-propanediol

Downstream raw materials:

3-(tetrahydropyranyloxy)-2,2-diphenylpropan-1-al

4-methyl-2,2-diphenyl-3-penten-1-al

4-methyl-2,2-diphenyl-3-penten-1-ol

1,1-dicyano-5-methyl-3,3-diphenyl-1,4-hexadiene