(3As,6E,10E,11aS)-6,10-dimethyl-3-methylidene-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-2-one

Base Information

Chemical Name:(3As,6E,10E,11aS)-6,10-dimethyl-3-methylidene-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-2-one
CAS No.:553-21-9
Molecular Formula:C15H20O2
Molecular Weight:232.323
Hs Code.:29322090
European Community (EC) Number:683-148-4
Metabolomics Workbench ID:49990
Wikidata:Q105032896
Wikipedia:Costunolide
Mol file:553-21-9.mol

Synonyms:costunolide;isocostunolide

Suppliers and Price of (3As,6E,10E,11aS)-6,10-dimethyl-3-methylidene-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Costunolide
1mg
$ 325.00

Usbiological
Costunolide
20mg
$ 297.00

TRC
(+)-Costunolide
10 mg
$ 95.00

TRC
(+)-Costunolide
25 mg
$ 190.00

Tocris
Costunolide ≥97%(HPLC)
1
$ 83.00

Tocris
Costunolide ≥97%(HPLC)
10
$ 175.00

TCI Chemical
Costunolide >95.0%(HPLC)
100mg
$ 420.00

TCI Chemical
Costunolide >95.0%(HPLC)
25mg
$ 153.00

Sigma-Aldrich
Costunolide ≥97% (HPLC)
5mg
$ 97.10

Sigma-Aldrich
Costunolide ≥97% (HPLC)
25mg
$ 384.00

Total 94 raw suppliers

Chemical Property of (3As,6E,10E,11aS)-6,10-dimethyl-3-methylidene-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-2-one

Chemical Property:

Vapor Pressure:3.8E-06mmHg at 25°C
Melting Point:106-109oC
Refractive Index:1.519
Boiling Point:385.4 °C at 760 mmHg
Flash Point:162 °C
PSA：26.30000
Density:1.03 g/cm³
LogP:3.55080
Storage Temp.:Store at -20°C
Solubility.:DMSO: soluble10mg/mL (clear solution)
XLogP3:2.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:232.146329876
Heavy Atom Count:17
Complexity:401

Purity/Quality:

95%-98% ^*data from raw suppliers

Costunolide ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-24/25

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CCCC(=CC2C(CC1)C(=C)C(=O)O2)C
Isomeric SMILES:C/C/1=C\CC/C(=C/[C@H]2[C@@H](CC1)C(=C)C(=O)O2)/C
Description Costunolide is a germacranolide sesquiterpene lactone extracted from costus oil. With alantolactone and dehydrocostuslactone, it is a component of lactone mix used to elicit reactions in Compositae-sensitive patients. An erythema-multiform-like occupational contact dermatitis case occurred in a chemistry student after accidental exposure to costus oil (CJ Le Coz & JP Lepoittevin, unpublished results).
Uses Costunolide is the oil extracted from Saussurea lappa is used in perfumery and in the Orient for all kinds of diseases. (+)-Costunolide is an inhibitor of osteoclast differentiation, acting as an anti-inflammatory and anti-oxidant agent. It is a sesquiterpene lactone which mediates apoptosis.

Technology Process of (3As,6E,10E,11aS)-6,10-dimethyl-3-methylidene-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-2-one

There total 30 articles about (3As,6E,10E,11aS)-6,10-dimethyl-3-methylidene-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%