ethyl 2-[(2-chloro-5-methyl-6-phenylpyridin-3-yl)(hydroxy)methyl]acrylate

Base Information

• Chemical Name: ethyl 2-[(2-chloro-5-methyl-6-phenylpyridin-3-yl)(hydroxy)methyl]acrylate
• CAS No.: 909777-06-6
• Molecular Formula: C₁₈H₁₈ClNO₃
• Molecular Weight: 331.799
• Mol file: 909777-06-6.mol

Synonyms:ethyl 2-[(2-chloro-5-methyl-6-phenylpyridin-3-yl)(hydroxy)methyl]acrylate

Chemical Property of ethyl 2-[(2-chloro-5-methyl-6-phenylpyridin-3-yl)(hydroxy)methyl]acrylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-[(2-chloro-5-methyl-6-phenylpyridin-3-yl)(hydroxy)methyl]acrylate

There total 1 articles about ethyl 2-[(2-chloro-5-methyl-6-phenylpyridin-3-yl)(hydroxy)methyl]acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-chloro-5-methyl-6-phenylnicotinaldehyde (876345-31-2) + ethyl acrylate (140-88-5,9003-32-1) → ethyl 2-[(2-chloro-5-methyl-6-phenylpyridin-3-yl)(hydroxy)methyl]acrylate (909777-06-6)

Guidance literature:

1,4-diaza-bicyclo[2.2.2]octane; at 20 ℃; for 0.0833333h; Product distribution / selectivity; Neat (no solvent);

Reference yield:

ethyl 2-[(2-chloro-5-methyl-6-phenylpyridin-3-yl)(hydroxy)methyl]acrylate (909777-06-6) → 2-[1-(2-Chloro-5-methyl-6-phenyl-pyridin-3-yl)-meth-(E)-ylidene]-4-nitro-pentanoic acid ethyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 0 - 5 °C

2: potassium carbonate / dimethylformamide / 20 °C

With dmap; potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2006.02.020

Reference yield:

ethyl 2-[(2-chloro-5-methyl-6-phenylpyridin-3-yl)(hydroxy)methyl]acrylate (909777-06-6) → 2-[1-(2-Chloro-5-methyl-6-phenyl-pyridin-3-yl)-meth-(E)-ylidene]-4-cyano-pentanedioic acid diethyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 0 - 5 °C

2: potassium carbonate / dimethylformamide / 20 °C

With dmap; potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2006.02.020

upstream raw materials:

2-chloro-5-methyl-6-phenylnicotinaldehyde

ethyl acrylate