(R)-4-benzyl-3-(3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-propanoyl)oxazolidin-2-one

Base Information

Chemical Name:(R)-4-benzyl-3-(3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-propanoyl)oxazolidin-2-one
CAS No.:1312136-34-7
Molecular Formula:C₁₈H₂₃NO₅
Molecular Weight:333.384
Hs Code.:

Synonyms:(R)-4-benzyl-3-(3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-propanoyl)oxazolidin-2-one

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Chemical Property of (R)-4-benzyl-3-(3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-propanoyl)oxazolidin-2-one

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Technology Process of (R)-4-benzyl-3-(3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-propanoyl)oxazolidin-2-one

There total 6 articles about (R)-4-benzyl-3-(3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-propanoyl)oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 40217-17-2,90719-32-7,120574-96-1,102029-44-7
(R)-4-(phenylmethyl)-2-oxazolidinone

: 173152-85-7
(R)-3-(2,2-dimethyl-1,3-dioxolan-4-yl)propionic acid

: 1312136-34-7
(R)-4-benzyl-3-(3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-propanoyl)oxazolidin-2-one

Guidance literature:: (R)-3-(2,2-dimethyl-1,3-dioxolan-4-yl)propionic acid; With pivaloyl chloride; triethylamine; In tetrahydrofuran; at 0 ℃; for 2h; Inert atmosphere;

(R)-4-(phenylmethyl)-2-oxazolidinone; With lithium chloride; In tetrahydrofuran; at 20 ℃; Inert atmosphere;
DOI:10.3390/molecules16075422

Reference yield:

: C₁₃H₂₂O₅

: 40217-17-2,90719-32-7,120574-96-1,102029-44-7
(R)-4-(phenylmethyl)-2-oxazolidinone

: 1312136-34-7
(R)-4-benzyl-3-(3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-propanoyl)oxazolidin-2-one

Guidance literature:: With lithium chloride; In tetrahydrofuran; at 20 ℃; Inert atmosphere;
DOI:10.1021/ol201547q

Reference yield:

: 322474-61-3
C₉H₁₆O₄

: 1312136-34-7
(R)-4-benzyl-3-(3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-propanoyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hydroxide / tetrahydrofuran; water / 3 h / 0 °C / Inert atmosphere

1.2: pH 4 / Inert atmosphere

2.1: pivaloyl chloride; triethylamine / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

With pivaloyl chloride; triethylamine; lithium hydroxide; In tetrahydrofuran; water;
DOI:10.3390/molecules16075422