N-{4-[(3-chloro-4-thiophenoxyphenyl)amino]-3-cyano-6-quinolinyl}-2-propenamide

Base Information

Chemical Name:N-{4-[(3-chloro-4-thiophenoxyphenyl)amino]-3-cyano-6-quinolinyl}-2-propenamide
CAS No.:214486-84-7
Molecular Formula:C₂₅H₁₇ClN₄OS
Molecular Weight:456.955
Hs Code.:

Synonyms:N-{4-[(3-chloro-4-thiophenoxyphenyl)amino]-3-cyano-6-quinolinyl}-2-propenamide

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Chemical Property of N-{4-[(3-chloro-4-thiophenoxyphenyl)amino]-3-cyano-6-quinolinyl}-2-propenamide

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Technology Process of N-{4-[(3-chloro-4-thiophenoxyphenyl)amino]-3-cyano-6-quinolinyl}-2-propenamide

There total 5 articles about N-{4-[(3-chloro-4-thiophenoxyphenyl)amino]-3-cyano-6-quinolinyl}-2-propenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 214485-17-3
6-amino-4-[(3-chloro-4-thiophenoxy)phenylamino]-quinoline-3-carbonitrile

: 814-68-6,25189-84-8
acryloyl chloride

: 214486-84-7
N-{4-[(3-chloro-4-thiophenoxyphenyl)amino]-3-cyano-6-quinolinyl}-2-propenamide

Guidance literature:: With triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 ℃; for 1.75h;

Reference yield:

: 214470-35-6,2305-65-9
6-nitro-4-oxo-1,4-dihydro-quinoline-3-carbonitrile

: 214486-84-7
N-{4-[(3-chloro-4-thiophenoxyphenyl)amino]-3-cyano-6-quinolinyl}-2-propenamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: trichlorophosphate / 5.5 h / Heating / reflux

2.1: ethanol / 8 h / Heating / reflux

3.1: ethanol; tin(ll) chloride / 2 h / Heating / reflux

3.2: 2 h

4.1: triethylamine / tetrahydrofuran; N,N-dimethyl-formamide / 1.75 h / 0 °C

With ethanol; triethylamine; tin(ll) chloride; trichlorophosphate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 2458-24-4
2-cyano-3-(4-nitro-phenylamino)-acrylic acid ethyl ester

: 214486-84-7
N-{4-[(3-chloro-4-thiophenoxyphenyl)amino]-3-cyano-6-quinolinyl}-2-propenamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: diphenyl ether-biphenyl eutectic / 12.5 h / 260 °C

2.1: trichlorophosphate / 5.5 h / Heating / reflux

3.1: ethanol / 8 h / Heating / reflux

4.1: ethanol; tin(ll) chloride / 2 h / Heating / reflux

4.2: 2 h

5.1: triethylamine / tetrahydrofuran; N,N-dimethyl-formamide / 1.75 h / 0 °C

With diphenyl ether-biphenyl eutectic; ethanol; triethylamine; tin(ll) chloride; trichlorophosphate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;