3-(2-chloropyrimidin-4-yl)-7-nitro-1H-indole

Base Information

• Chemical Name: 3-(2-chloropyrimidin-4-yl)-7-nitro-1H-indole
• CAS No.: 1214264-48-8
• Molecular Formula: C₁₂H₇ClN₄O₂
• Molecular Weight: 274.666
• Mol file: 1214264-48-8.mol

Synonyms:3-(2-chloropyrimidin-4-yl)-7-nitro-1H-indole

Chemical Property of 3-(2-chloropyrimidin-4-yl)-7-nitro-1H-indole

Chemical Property:

• Melting Point: 205 °C
• Boiling Point: 597.4±40.0 °C(Predicted)
• PKA: 11.97±0.30(Predicted)
• Density: 1.548±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2-chloropyrimidin-4-yl)-7-nitro-1H-indole

There total 7 articles about 3-(2-chloropyrimidin-4-yl)-7-nitro-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

3-(2-chloro-4-pyrimidinyl)-1-[(4-methylphenyl)sulfonyl]-7-nitro-1H-indole → 3-(2-chloropyrimidin-4-yl)-7-nitro-1H-indole (1214264-48-8)

Guidance literature:

With water; sodium hydroxide; In tetrahydrofuran; at 50 ℃; for 2h;

Reference yield: 38.0%

2-chloro-4-ethynylpyrimidine (37968-69-7) + o-nitronitrosobenzene (612-29-3) → 3-(2-chloropyrimidin-4-yl)-7-nitro-1H-indole (1214264-48-8)

Guidance literature:

In toluene; at 80 ℃; for 6h; Inert atmosphere;

DOI:10.1016/j.tet.2009.12.020

Reference yield:

2,6-Dichloropyrimidine (3934-20-1) + 7-nitro-1H-indole (6960-42-5) → 3-(2-chloropyrimidin-4-yl)-7-nitro-1H-indole (1214264-48-8)

Guidance literature:

2,6-Dichloropyrimidine; With aluminum (III) chloride; In 1,2-dichloro-ethane; for 0.0833333h; Inert atmosphere;

7-nitro-1H-indole; In 1,2-dichloro-ethane; at 85 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.bioorg.2021.105537

upstream raw materials:

2-chloro-4-ethynylpyrimidine

o-nitronitrosobenzene

1-[(4-methylphenyl)sulfonyl]-7-nitro-1H-indole

7-nitro-1H-indole

Downstream raw materials:

(2R)-N-(3-{2-[(3-methoxy-1-methyl-1H-pyrazol-4-yl)amino]pyrimidin-4-yl}-1H-indol-7-yl)-2-(4-methylpiperazin-1-yl)propanamide