(S)-N-acetyl-3-(2-ethynyl-3,4,5-trimethoxyphenyl)-1-(2-oxazolyl)-propylamine

Base Information

Chemical Name:(S)-N-acetyl-3-(2-ethynyl-3,4,5-trimethoxyphenyl)-1-(2-oxazolyl)-propylamine
CAS No.:206195-23-5
Molecular Formula:C₁₉H₂₂N₂O₅
Molecular Weight:358.394
Hs Code.:

Synonyms:(S)-N-acetyl-3-(2-ethynyl-3,4,5-trimethoxyphenyl)-1-(2-oxazolyl)-propylamine

Suppliers and Price of (S)-N-acetyl-3-(2-ethynyl-3,4,5-trimethoxyphenyl)-1-(2-oxazolyl)-propylamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-N-acetyl-3-(2-ethynyl-3,4,5-trimethoxyphenyl)-1-(2-oxazolyl)-propylamine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-N-acetyl-3-(2-ethynyl-3,4,5-trimethoxyphenyl)-1-(2-oxazolyl)-propylamine

There total 11 articles about (S)-N-acetyl-3-(2-ethynyl-3,4,5-trimethoxyphenyl)-1-(2-oxazolyl)-propylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 108-24-7
acetic anhydride

: 327024-98-6
(S)-3-(2-Ethynyl-3,4,5-trimethoxy-phenyl)-1-oxazol-2-yl-propylamine

: 206195-23-5
(S)-N-acetyl-3-(2-ethynyl-3,4,5-trimethoxyphenyl)-1-(2-oxazolyl)-propylamine

Guidance literature:: With dmap; triethylamine; In diethyl ether; at 20 ℃; for 7h;
DOI:10.1016/S0040-4020(00)00862-0

Reference yield:

: 53560-26-2
3-(3,4,5-trimethoxyphenyl)propan-1-ol

: 206195-23-5
(S)-N-acetyl-3-(2-ethynyl-3,4,5-trimethoxyphenyl)-1-(2-oxazolyl)-propylamine

Guidance literature:: Multi-step reaction with 11 steps

1.1: 98 percent / 2,6-lutidine / CH₂Cl₂ / 5 h / 20 °C

2.1: 95 percent / silver trifluoroacetate; I₂; sodium bicarbonate / CHCl₃ / 3 h / 0 °C

3.1: 92 percent / Et₂NH; bis[triphenylphosphine]palladium dichloride; copper(I) iodide / dimethylsulfoxide / 20 h / 90 °C

4.1: 98 percent / n-Bu₄NF / tetrahydrofuran / 7 h / 20 °C

5.1: 96 percent / oxalyl chloride; DMSO / CH₂Cl₂ / 0.75 h / -78 °C

6.1: BH₃*THF / tetrahydrofuran / 1 h / 20 °C

6.2: t-BuLi / pentane; tetrahydrofuran / 0.67 h / -78 °C

6.3: 64 percent / tetrahydrofuran; pentane / 3 h / -78 °C

7.1: 96 percent / oxalyl chloride; DMSO / CH₂Cl₂ / 0.5 h / -78 °C

8.1: 85 percent / BH₃*THF; (S)-(-)-2-amino-3-methyl-1,1-diphenylbutan-1-ol / tetrahydrofuran / 6 h / 23 °C

9.1: 60 percent / diphenylphosphoryl azide; triphenylphosphine; diisopropylazodicarboxylate / tetrahydrofuran / 12 h / 20 °C

10.1: 95 percent / Ph₃P / tetrahydrofuran; H₂O / 50 h / 20 °C

11.1: 98 percent / DMAP; Et₃N / diethyl ether / 7 h / 20 °C

With 2,6-dimethylpyridine; dmap; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; borane-THF; oxalyl dichloride; di-isopropyl azodicarboxylate; diphenylphosphoranyl azide; tetrabutyl ammonium fluoride; iodine; silver trifluoroacetate; sodium hydrogencarbonate; 1,1-diphenyl-L-valinol; dimethyl sulfoxide; diethylamine; triethylamine; triphenylphosphine; In tetrahydrofuran; diethyl ether; dichloromethane; chloroform; water; dimethyl sulfoxide; 3.1: Sonogashira coupling / 5.1: Swern oxidation / 7.1: Swern oxidation;
DOI:10.1016/S0040-4020(00)00862-0

Reference yield:

: 327025-04-7
5-(3-triisopropylsiloxypropyl)-4-iodo-1,2,3-trimethoxybenzene

: 206195-23-5
(S)-N-acetyl-3-(2-ethynyl-3,4,5-trimethoxyphenyl)-1-(2-oxazolyl)-propylamine

Guidance literature:: Multi-step reaction with 9 steps

1.1: 92 percent / Et₂NH; bis[triphenylphosphine]palladium dichloride; copper(I) iodide / dimethylsulfoxide / 20 h / 90 °C

2.1: 98 percent / n-Bu₄NF / tetrahydrofuran / 7 h / 20 °C

3.1: 96 percent / oxalyl chloride; DMSO / CH₂Cl₂ / 0.75 h / -78 °C

4.1: BH₃*THF / tetrahydrofuran / 1 h / 20 °C

4.2: t-BuLi / pentane; tetrahydrofuran / 0.67 h / -78 °C

4.3: 64 percent / tetrahydrofuran; pentane / 3 h / -78 °C

5.1: 96 percent / oxalyl chloride; DMSO / CH₂Cl₂ / 0.5 h / -78 °C

6.1: 85 percent / BH₃*THF; (S)-(-)-2-amino-3-methyl-1,1-diphenylbutan-1-ol / tetrahydrofuran / 6 h / 23 °C

7.1: 60 percent / diphenylphosphoryl azide; triphenylphosphine; diisopropylazodicarboxylate / tetrahydrofuran / 12 h / 20 °C

8.1: 95 percent / Ph₃P / tetrahydrofuran; H₂O / 50 h / 20 °C

9.1: 98 percent / DMAP; Et₃N / diethyl ether / 7 h / 20 °C

With dmap; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; borane-THF; oxalyl dichloride; di-isopropyl azodicarboxylate; diphenylphosphoranyl azide; tetrabutyl ammonium fluoride; 1,1-diphenyl-L-valinol; dimethyl sulfoxide; diethylamine; triethylamine; triphenylphosphine; In tetrahydrofuran; diethyl ether; dichloromethane; water; dimethyl sulfoxide; 1.1: Sonogashira coupling / 3.1: Swern oxidation / 5.1: Swern oxidation;
DOI:10.1016/S0040-4020(00)00862-0