(R)-(4-methoxy-6-[((S)-1-phenylethylamino)methyl]-pyridin-2-yl)(phenyl)methanol

Base Information

Chemical Name:(R)-(4-methoxy-6-[((S)-1-phenylethylamino)methyl]-pyridin-2-yl)(phenyl)methanol
CAS No.:1351610-59-7
Molecular Formula:C₂₂H₂₄N₂O₂
Molecular Weight:348.445
Hs Code.:

Synonyms:(R)-(4-methoxy-6-[((S)-1-phenylethylamino)methyl]-pyridin-2-yl)(phenyl)methanol

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Chemical Property of (R)-(4-methoxy-6-[((S)-1-phenylethylamino)methyl]-pyridin-2-yl)(phenyl)methanol

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Technology Process of (R)-(4-methoxy-6-[((S)-1-phenylethylamino)methyl]-pyridin-2-yl)(phenyl)methanol

There total 4 articles about (R)-(4-methoxy-6-[((S)-1-phenylethylamino)methyl]-pyridin-2-yl)(phenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1351610-52-0
C₂₈H₃₈N₂O₂Si

: 1351610-59-7
(R)-(4-methoxy-6-[((S)-1-phenylethylamino)methyl]-pyridin-2-yl)(phenyl)methanol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.tetasy.2011.08.017

Reference yield:

: C₂₈H₃₆N₂O₂Si

: 1351610-59-7
(R)-(4-methoxy-6-[((S)-1-phenylethylamino)methyl]-pyridin-2-yl)(phenyl)methanol

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate; ethanol / 4 h / 20 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; ethanol; tetrabutyl ammonium fluoride; In tetrahydrofuran;
DOI:10.1016/j.tetasy.2011.08.017

Reference yield:

: 1351610-51-9
(R)-6-[(tert-butyldimethylsiloxy)(phenyl)methyl]-4-methoxypicolinaldehyde

: 1351610-59-7
(R)-(4-methoxy-6-[((S)-1-phenylethylamino)methyl]-pyridin-2-yl)(phenyl)methanol

Guidance literature:: Multi-step reaction with 3 steps

1: magnesium sulfate / dichloromethane / 20 h / 20 °C / Inert atmosphere

2: sodium tetrahydroborate; ethanol / 4 h / 20 °C / Inert atmosphere

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; ethanol; tetrabutyl ammonium fluoride; magnesium sulfate; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tetasy.2011.08.017