ethyl (3aS,5S,12aS)-10,11-dibromo-5-isopropoxy-2,8-dioxo-3-(tosyloxy)-2,3,5,6,8,12a-hexahydroimidazo[4,5-b]dipyrrolo[1,2-a:1',2'-d]pyrazine-1(4H)-carboxylate

Base Information

Chemical Name:ethyl (3aS,5S,12aS)-10,11-dibromo-5-isopropoxy-2,8-dioxo-3-(tosyloxy)-2,3,5,6,8,12a-hexahydroimidazo[4,5-b]dipyrrolo[1,2-a:1',2'-d]pyrazine-1(4H)-carboxylate
CAS No.:1372717-52-6
Molecular Formula:C₂₄H₂₆Br₂N₄O₈S
Molecular Weight:690.366
Hs Code.:

ethyl (3aS,5S,12aS)-10,11-dibromo-5-isopropoxy-2,8-dioxo-3-(tosyloxy)-2,3,5,6,8,12a-hexahydroimidazo[4,5-b]dipyrrolo[1,2-a:1',2'-d]pyrazine-1(4H)-carboxylate

Synonyms:ethyl (3aS,5S,12aS)-10,11-dibromo-5-isopropoxy-2,8-dioxo-3-(tosyloxy)-2,3,5,6,8,12a-hexahydroimidazo[4,5-b]dipyrrolo[1,2-a:1',2'-d]pyrazine-1(4H)-carboxylate

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Chemical Property of ethyl (3aS,5S,12aS)-10,11-dibromo-5-isopropoxy-2,8-dioxo-3-(tosyloxy)-2,3,5,6,8,12a-hexahydroimidazo[4,5-b]dipyrrolo[1,2-a:1',2'-d]pyrazine-1(4H)-carboxylate

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Technology Process of ethyl (3aS,5S,12aS)-10,11-dibromo-5-isopropoxy-2,8-dioxo-3-(tosyloxy)-2,3,5,6,8,12a-hexahydroimidazo[4,5-b]dipyrrolo[1,2-a:1',2'-d]pyrazine-1(4H)-carboxylate

There total 3 articles about ethyl (3aS,5S,12aS)-10,11-dibromo-5-isopropoxy-2,8-dioxo-3-(tosyloxy)-2,3,5,6,8,12a-hexahydroimidazo[4,5-b]dipyrrolo[1,2-a:1',2'-d]pyrazine-1(4H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1372717-45-7
ethyl (3aS,5R,12aS)-10,11-dibromo-2,8-dioxo-3-(tosyloxy)-5-[{(trifluoromethyl)sulfonyl}oxy]-2,3,5,6,8,12a-hexahydroimidazo[4,5-b]dipyrrolo[1,2-a:1',2'-d]pyrazine-1(4H)-carboxylate

: 67-63-0,8013-70-5
isopropyl alcohol

: 1372717-52-6
ethyl (3aS,5S,12aS)-10,11-dibromo-5-isopropoxy-2,8-dioxo-3-(tosyloxy)-2,3,5,6,8,12a-hexahydroimidazo[4,5-b]dipyrrolo[1,2-a:1',2'-d]pyrazine-1(4H)-carboxylate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 36h;
DOI:10.1002/ejoc.201101175

Reference yield:

: 1372717-35-5
C₂₁H₂₀Br₂N₄O₈S

: 1372717-52-6
ethyl (3aS,5S,12aS)-10,11-dibromo-5-isopropoxy-2,8-dioxo-3-(tosyloxy)-2,3,5,6,8,12a-hexahydroimidazo[4,5-b]dipyrrolo[1,2-a:1',2'-d]pyrazine-1(4H)-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 1.17 h / 0 °C

2: triethylamine / dichloromethane / 36 h / 20 °C

With pyridine; triethylamine; In dichloromethane;
DOI:10.1002/ejoc.201101175

Reference yield:

: 1000612-08-7
C₂₁H₂₂N₄O₈S

: 1372717-52-6
ethyl (3aS,5S,12aS)-10,11-dibromo-5-isopropoxy-2,8-dioxo-3-(tosyloxy)-2,3,5,6,8,12a-hexahydroimidazo[4,5-b]dipyrrolo[1,2-a:1',2'-d]pyrazine-1(4H)-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: N-Bromosuccinimide / dichloromethane / 24 h / 20 °C

2: pyridine / dichloromethane / 1.17 h / 0 °C

3: triethylamine / dichloromethane / 36 h / 20 °C

With pyridine; N-Bromosuccinimide; triethylamine; In dichloromethane;
DOI:10.1002/ejoc.201101175